Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans

Authors

  • Letícia Fernandes da Rocha Universidade Federal do Rio Grande do Sul, Faculade de Farmácia
  • Bruna Pippi Universidade Federal do Rio Grande do Sul, Programa de Pós-Graduação em Microbiologia Agrícola e do Ambiente
  • Alexandre Meneghello Fuentefria Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Departamento de Análises
  • Adelina Mezzari Universidade Federal do Rio Grande do Sul, Faculdade de Farmácia, Departamento de Análises https://orcid.org/0000-0003-4538-627X

DOI:

https://doi.org/10.1590/s2175-97902019000318599

Keywords:

Cryptococcus neoformans, Ibuprofen, Itraconazole, Fluconazole, Synergism

Abstract

The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.

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Published

2021-03-02

How to Cite

Rocha, L. F. da, Pippi, B. ., Fuentefria, A. M. ., & Mezzari, A. . (2021). Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans. Brazilian Journal of Pharmaceutical Sciences, 56, e18599 . https://doi.org/10.1590/s2175-97902019000318599

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