Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil

Authors

  • Marianne Silveira Camargo Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde, Programa de Residência
  • Márcio Galvão Oliveira Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde, Programa de Pós-Graduação em Saúde Coletiva
  • Sostenes Mistro Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde, Programa de Pós-Graduação em Saúde Coletiva https://orcid.org/0000-0001-5840-820X
  • Izabel Cristina Pereira Rocha Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde
  • Camila Neto Santos Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde
  • Caroline Tianeze de Castro Universidade Federal da Bahia, Instituto Multidisciplinar em Saúde
  • Luiz Carlos Santana Passos Universidade Federal da Bahia, Programa de Pós-Graduação em Medicina e Saúde

DOI:

https://doi.org/10.1590/s2175-97902020000117837

Keywords:

Intensive Care Units, Glomerular Filtration Rate, Anti-infective Agents, Renal Insufficiency

Abstract

Objectives. This study sought to compare the estimated glomerular filtration rate and the indication of dose adjustment of antimicrobials when using Cockcroft-Gault or Modification of Diet in Renal Disease. Methods. A cross-sectional study was performed with patients admitted to the intensive care unit of a Brazilian general hospital. The glomerular filtration rate was calculated for patients on all days using the Cockcroft-Gault and Modification of Diet in Renal Disease equations. The difference in estimated glomerular filtration and the dose adjustment indication of antimicrobials were assessed. Results. A total of 631 patients were included in this study. The median estimated glomerular filtration was significantly higher when estimated using Modification of Diet in Renal Disease (100.3 mL/ min/1.73 m²) than the estimation by Cockcroft-Gault (83.2 mL/min) [p<0.001]. Greater differences in estimations produced by the two formulae were observed in patients at extremes of weight and age, and a different dose adjustment was indicated for all antimicrobials assessed. Conclusions. These results demonstrate a significant difference in estimated glomerular filtration rate values when calculated using either Cockcroft-Gault or Modification of Diet in Renal Disease as well as in the indication of dose adjustment in an intensive care unit.

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Published

2020-12-09

How to Cite

Camargo, M. S. ., Oliveira, M. G. ., Mistro, S. ., Rocha, I. C. P. ., Santos, C. N., Castro, C. T. de ., & Passos, L. C. S. . (2020). Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil. Brazilian Journal of Pharmaceutical Sciences, 56, e17837. https://doi.org/10.1590/s2175-97902020000117837

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