Costus root aqueous extract modulates rat liver toxicity, DNA damage, injury, proliferation alterations induced by plant growth regulator Ethephon

Authors

  • Ehab Tousson Tanta University, Faculty of Science, Department of Zoology https://orcid.org/0000-0001-9722-3603
  • Afaf El-Atrsh Tanta University, Faculty of Science, Department of Zoology
  • Merfaat Mansour Tanta University, Faculty of Science, Department of Zoology
  • Abdallah Assem Tanta University, Faculty of Science, Department of Zoology

DOI:

https://doi.org/10.1590/s2175-97902019000318500

Keywords:

Plant growth regulator, Ethephon, Costus, Liver, DNA damage, PCNA expression, Rat

Abstract

Ethephon (Ethrel®) is an ethylene-based plant growth regulator that used in agriculture and it has direct and indirect effects on human health, direct effect via its inhalation during usage in agriculture and indirect effect through the diet (Fruits and vegetables) that is sprayed with it. The current study aimed to examine the possible modifying effects of costus (Saussurea lappa) root aqueous extract against Ethephon induced liver toxicity, injury, DNA fragmentation and PCNA alterations in male rats. Fifty adult male rats were divided into 5 groups (1st, control; 2nd, Costus; 3rd, Ethephon; 4th, Post treated Ethephon with costus; 5th, self-healing Ethephon). Current results revealed that; a significant increase in aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), liver injury, DNA damage and PCNA expressions in Ethephon group when compared with control group. In contrast; a significant decrease in albumin and total proteins in Ethephon group when compared with control group. Treatment of rats with costus after Ethephon improved these alterations as compared with Ethephon self-healing. So, it could be concluded that costus root extract worth to be considered as a natural substance for ameliorating the hepatic toxicity induced by plant growth regulator Ethephon.

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Published

2020-12-09

How to Cite

Tousson, E. ., El-Atrsh, A. ., Mansour, M. ., & Assem, A. . (2020). Costus root aqueous extract modulates rat liver toxicity, DNA damage, injury, proliferation alterations induced by plant growth regulator Ethephon. Brazilian Journal of Pharmaceutical Sciences, 56, e18500 . https://doi.org/10.1590/s2175-97902019000318500

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