Levels of BPA in makdous, a traditional Syrian food, using solid-phase extraction followed by HPLC
DOI:
https://doi.org/10.1590/s2175-97902020000419094Keywords:
BPA. Makdous. Syrian traditional dish. Dietary exposure assessment. HPLC.Abstract
Bisphenol A (BPA), an endocrine disrupter, can migrate from packaging material into food stuff. This research was designed to measure BPA levels in makdous, a traditional Syrian food. Forty three samples of makdous stored in different plastic containers (polyethylene (PE), polypropylene (PP), and unspecified plastic containers) were analyzed every 3 months for one year beginning July 2017. Quantification of BPA was carried out by an RP-HPLC system equipped with fluorescence detector after solid phase extraction. Migration was found in PE and PP plastic containers with slight differences. Statistically significant differences in BPA levels were observed between samples assayed after two weeks of preparation and samples assayed after 12 months (mean 16.32 vs. 38.26 μg/kg, p value=0.003). According to these amounts, BPA levels were all under the specific migration limit of 0.05 mg/kg as newly referred in Regulation (EU) No 2018/213. These levels of exposure would only contribute to 2.15% and 2.75% of the EFSA t-TDI in both men and women respectively based on mean dietary exposure estimates derived from a 24-h dietary information study from 875 participants. Hence there are no concerns about potential health risks from makdous consumption.
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Abou Omar TF, Sukhn C, Fares SA, Abiad MG, Habib RR, Dhaini HR. Bisphenol A exposure assessment from olive oil consumption. Environ Monit Assess. 2017;189(7):341.
Arvanitoyannis IS, Bosnea L. Migration of substances from food packaging materials to foods. Crit Rev Food Sci Nutr. 2004;44(2):63-76.
Bendito MD, Bravo SR, Reyes ML, Prieto AG. Determination of bisphenol A in canned fatty foods by coacervative microextraction, liquid chromatography and fluorimetry. Food Addit Contam. 2009;26(2):265-274.
Biedermann S, Tschudin P, Grob, K. Transfer of bisphenol A from thermal printer paper to the skin. Anal Bioanal Chem. 2010;398(1):571-576.
Birnbaum LS, Aungst J, Schug TT, Goodman JL. Working together: research- and science-based regulation of BPA. Environ Health Perspect. 2013;121(7):A206-7.
Bosquiazzo VL, Varayoud J, Munoz-de-Toro M, Luque EH, Ramos JG. Effects of neonatal exposure to bisphenol A on steroid regulation of vascular endothelial growth factor expression and endothelial cell proliferation in the adult rat uterus. Biol Reprod. 2010;82(1):86-95.
Bushnik T, Haines D, Levallois P, Levesque J, Van Oostdam J, Viau C. Lead and bisphenol A concentrations in the Canadian population. Health Rep. 2010;21(3):7-18.
Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect. 2008;116(1):39-44.
Commission Regulation (EU). On the use of bisphenol A in varnishes and coatings intended to come into contact with food and amending Regulation (EU) No 10/2011 as regards the use of that substance in plastic food contact materials. Commission Regulation (EU) 2018/213, 12 February 2018.
Ehlert KA, Beumer CWE, Groot MCE. Migration of bisphenol A into water from polycarbonate baby bottles during microwave heating. Food Addit Contam . 2008;25(7):904-910.
European Food Safety Agency (EFSA). Scientific opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. EFSA J. 2015;13:3978-4617.
Frederiksen H, Aksglaede L, Sorensen K, Nielsen O, Main KM, Skakkebaek NE et al Bisphenol A and other phenols in urine from Danish children and adolescents analyzed by isotope diluted TurboFlow-LC-MS/MS. Int J Hyg Environ Health. 2013;216(6):710-720.
Gao Y, Gu Y, Wei Y. Determination of polymer compounds-antioxidants and ultraviolet (UV) absorbers by high-performance liquid chromatography coupled with UV photodiode array detection in food simulants. J Agric Food Chem. 2011;59(24):12982-12989.
Ho SM, Tang WY, Belmonte de Frausto J, Prins GS. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res. 2006;66(11):5624-5632.
Hoekstra EJ, Simoneau C. Release of bisphenol A from polycarbonate: A review. Crit Rev Food Sci Nutr. 2013;53(4):386-402.
Huang YQ, Wong CK, Zheng JS, Bouwman H, Barra R, Wahlstrom B et al Bisphenol A (BPA) in China: a review of sources, environmental levels, and potential human health impacts. Environ Int. 2012;42:91-99.
Kang J-h, Kito K, Kondo F. Factors influencing the migration of bisphenol A from cans. J Food Prot. 2003;66(8):1444-1447.
Kiely M, Faughnan M, Wähälä K, Brants H, Mulligan A. Phyto-oestrogen levels in foods: the design and construction of the VENUS database. Br J Nutr. 2003;89(1):S19-23.
Kiritsakis A, Kanavouras A, Kiritsakis K. Chemical analysis, quality control and packaging issues of olive oil. Eur J Lipid Sci Technol. 2002;104(9-10):628-638.
Komada M, Asai Y, Morii M, Matsuki M, Sato M, Nagao T. Maternal bisphenol A oral dosing relates to the acceleration of neurogenesis in the developing neocortex of mouse fetuses. Toxicology. 2012;295(1-3):31-8.
Kubwabo C, Kosarac I, Stewart B, Gauthier BR, Lalonde K, Lalonde PJ. Migration of bisphenol A from plastic baby bottles, baby bottle liners and reusable polycarbonate drinking bottles. Food Addit Contam: Part A. 2009;26(6):928-937.
La Pensee EW, La Pensee CR, Fox S, Schwemberger S, Afton S, Ben-Jonathan N. Bisphenol A and estradiol are equipotent in antagonizing cisplatininduced cytotoxicity in breast cancer cells. Cancer Lett. 2010;290(2):167-73.
Li D, Zhou Z, Qing D, He Y, Wu T, Miao M et al. Occupational exposure to bisphenol-A (BPA) and the risk of self-reported male sexual dysfunction. Hum Reprod. 2010;25(2):519-27.
Ohtani N, Suda K, Tsuji E, Tanemura K, Yokota H, Inoue H et al Late pregnancy is vulnerable period for exposure to BPA. J Vet Med Sci. 2018;80(3):536-543.
Richter CA, Birnbaum LS, Farabollini F, Newbold RR, Rubin BS, Talsness CE et al In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol. 2007a;24:199-224.
Richter CA, Taylor JA, Ruhlen RL, Welshons WV, Vom Saal FS. Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells. Environ Health Perspect . 2007b;115(6):902-8.
Rochester JR. Bisphenol A and human health: a review of the literature. Reprod Toxicol. 2013;42:132-155.
Sadeghi M, Nematifar Z, Fattahi N, Pirsaheb M, Shamsipur M. Determination of bisphenol A in food and environmental samples using combined solid-phase extraction-dispersive liquid-liquid microextraction with solidification of floating organic drop followed by HPLC. Food Anal Methods. 2016;9(6):1814-1824.
Schecter A, Malik N, Haffner D, Smith S, Harris TR, Paepke O et al. Bisphenol A (BPA) in U.S. food. Environ Sci Technol. 2010;44(24):9425-30.
Sugiura-Ogasawara M, Ozaki Y, Sonta S, Makino T, Suzumori K. Exposure to bisphenol A is associated with recurrent miscarriage. Hum Reprod . 2005;20(8):2325-9.
Tawfik MS. Interaction of packaging materials and vegetable oils: global migration and oil absorption. J Food Sci Technol. 2005;3(4):506-510.
Thomson B, Cressey P, Shaw I. Dietary exposure to xenoestrogens in New Zealand. J Environ Monitor. 2003;5(2):229-235.
Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reprod Toxicol. 2007;24(2):139-177.
Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH et al. Hormones and endocrine disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev. 2012;33(3):378-455.
Vom Saal FS, Hughes C. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Environ Health Perspect . 2005;113(8):926-933.
Wang Q, Storm BK. Migration study of polypropylene (PP) oil blends in food simulants. Macromol Symp. 2006;242(1):307-314.
Zhang JH, Jiang M, Zou L, Shi D, Mei SR, Zhu YX et al. Selective solid-phase extraction of bisphenol A using molecularly imprinted polymers and its application to biological and environmental samples. Anal Bioanal Chem. 2006;385(4):780-6.
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