Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study

Authors

  • Maria Betânia de Freitas Marques Departamento de Farmácia, Faculdade de Biologia e Ciências da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil; Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0002-0561-2343
  • Osmar Patrício Almeida Departamento de Farmácia, Faculdade de Biologia e Ciências da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil
  • Bárbara Caroline Rodrigues Araújo Departamento de Farmácia, Faculdade de Biologia e Ciências da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil
  • José Domingos Ardisson Centro de Desenvolvimento da Tecnologia Nuclear, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • Rita de Cássia de Oliveira Sebastião Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Flávia Lidiane Oliveira da Silva Departamento de Farmácia, Faculdade de Biologia e Ciências da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil
  • Wagner da Nova Mussel Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
  • Maria Irene Yoshida Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil,
  • Guilherme Carneiro Departamento de Farmácia, Faculdade de Biologia e Ciências da Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil https://orcid.org/0000-0002-0367-8170

DOI:

https://doi.org/10.1590/s2175-97902023e21460

Keywords:

Pink clay mineral; Thermal behavior; Iron phases; Powder technology; Solid-state stability; Kinetic study

Abstract

Clay minerals are still widely used in pharmaceutical products for human health and cosmetic purposes. Pre-formulation studies were conducted to identify solid-state properties of pink clay, a sample from Diamantina, Brazil. Among the solid properties to be analyzed, we have selected type identification, iron phases, crystallinity, powder flow characteristics, thermal behavior, and non-isothermal phase transition kinetics. The pink clay is composed of (1:1) clay type and kaolinite as the main component. The Mössbauer spectrum of pink clay shows Fe3+(α-Fe2O3)

hematite, Fe2+, and Fe3+ with large Δ/2ξq of about 2.80 and 2.69 mm.s-1 respectively, related to iron silicates, most likely pyroxene, and a superparamagnetic Fe3+. Pink clay exhibits poor flow properties. The thermal behavior indicates a phase-transition between 400 - 600 ºC associated with the dehydroxylation of the pink clay system requiring ~300 kJ mol-1, being constant until the process reaches a conversion of ~50% when the energy is enhanced to ~530 kJ mol-1, concluding the whole dehydroxylation process (α=80%). Solid-state properties and characteristics found for the pink clay must be considered for the proper design of formulations. This type of clay shows unique pharmaceutical properties that can be favorably exploited by the cosmetic industry.

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Published

2023-05-08

Issue

Vol. 59 (2023)

Section

Original Article

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How to Cite

Solid-state properties of pink clay from Jequitinhonha Valley in Brazil for pre-formulation study. (2023). Brazilian Journal of Pharmaceutical Sciences, 59, e21460. https://doi.org/10.1590/s2175-97902023e21460

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