Synthesis and characterization of a cysteine xyloglucan conjugate as mucoadhesive polymer

Authors

  • Mangesh Bhalekar AISSMS College of Pharmacy,
  • Savita Sonawane Jawaharlal Nehru Technological University
  • Shamkant Shimpi APL Research Centre

DOI:

https://doi.org/10.1590/S1984-82502013000200010

Keywords:

Mucoadhesion, Thiomer, Xyloglucan, L-cysteine HCl

Abstract

The aim of this study was to improve the mucoadhesive potential of xyloglucan polymer by the covalent attachment of cysteine as thiol moiety. The parent polymer xyloglucan was chemically modified by introducing sulphydryl bearing compound L-cysteine HCl. Different batches of xyloglucan-cysteine conjugates were prepared at varying reaction pH (2-6) and evaluated for optimum thiol incorporation, disulphide group content, swelling behavior, rheological properties and mucoadhesive properties. The obtained conjugates characterized in vitro by quantification of immobilized thiol groups; showed maximum thiol incorporation on xyloglucan (7.67 ± 0.14 %) at pH 5. The disulphide group content was found maximum (2.83 ± 0.12) at pH 6. The water uptake at end of 4 h was 5.0 for xyloglucan and was found to decrease in thiolated derivatives with increase in thiolation. Mucoadhesion studies revealed that mucoadhesion of xyloglucan-cysteine conjugate increased more than twice compared to the unmodified polymer. The viscosity of thiomer was more than that of xyloglucan because of formation of disulphide bonds.

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Published

2013-06-01

Issue

Section

Articles

How to Cite

Synthesis and characterization of a cysteine xyloglucan conjugate as mucoadhesive polymer . (2013). Brazilian Journal of Pharmaceutical Sciences, 49(2), 285-292. https://doi.org/10.1590/S1984-82502013000200010