The Brazilian Journal of Pharmaceutical Sciences (BJPS) is a peer-reviewed electronic journal published quarterly by the School of Pharmaceutical Sciences of the University of São Paulo.

The purpose of the Brazilian Journal of Pharmaceutical Sciences is to publish manuscripts that significantly contribute to knowledge in all areas of Pharmaceutical Sciences, including Medicines and Drugs, Pharmaceutical and Health Care, Food and Experimental Nutrition, Clinical Chemistry, Toxicology, Medicinal Chemistry, Pharmaceutical Technology, Biotechnology among others.
The following papers will not be accepted for publication:

• Studies on human subjects not approved by an accredited Ethics Committee or without written informed consent from the subject or legal guardian.
• Studies on animals not approved by an accredited Ethics and Animal Care Committee.
• Manuscripts describing plant extract activity that do not identify quali and quantitative markers of the extract.

Manuscripts that do not agree to the Instructions will be refused prior to peer review. 
Manuscripts must be submitted in English.

Submission of a manuscript to BJPS implies that the data have not been published previously and will not be submitted for publication elsewhere while the manuscript is under review.

Co-authors should be individuals who have contributed substantially to the content of the paper. 
Manuscripts in accordance to the “Preparing your manuscript section” will be submitted for peer review to at least two independent, anonymous referees indicated by the Associated Editors. Based on peer review, the Associate Editors will suggest manuscript acceptance or not to the Editor-in-Chief, who is responsible for the final decision.

In the case revision is suggested, the authors are asked to resubmit the manuscript incorporating the suggestions and recommendations of the referees within 15 calendar days. If the revised version is not received within the time specified from the date of notice, the manuscript process will be canceled. All revisions must be accompanied with a letter detailing the changes made to the original document and answering all the reviewer comments, on a point-by-point basis. All alterations must be identified in the revised manuscript.

Manuscripts must have their copyright assigned to the BJPS before submitting to the Journal.
The dates of receipt and acceptance will be published for each article. Authors are expected to return reviewed manuscripts to the Journal within 15 calendar days, and to return galley proofs of accepted manuscripts within 72 hours. The total number of "late" days will be added to the submission date at the time of publication.

Authors are required to suggest 4 potential reviewers with information of institutional and e-mail address. At least 2 of the potential reviewers suggested should be from a different country to the corresponding authors. The Editors reserve the right to indicate these or other reviewers for manuscript evaluation.

Manuscript categories
The authors should state in the cover letter that the manuscript is intended to be Full-length Original Paper, Short Communication, Review Article, Mini-review article, Concepts and Comments and Book Reviews.
The Journal will also publish Thematic or Congress Abstracts Supplements under invitation by the Editors or previous approval of the Editorial Board. 
BJPS will publish the following type of articles:

Full-length Original Paper
Each manuscript should clearly state its objective or hypothesis; the experimental design and methods used; the essential features of any interventions; the main outcome measures; the main results of the study; and a discussion placing the results in the context of published literature.
The manuscript should contain:

• abstract of no more than 250 words
• no more than 6 key words
• a running title to be used as a page heading, which should not exceed 60 letters and spaces
• manuscript main body divided into separate sections (Introduction, Material and Methods, Results and Discussion).
• no more than 40 references (without exceptions)
• Supplementary data can be submitted as Suppmentary information session.

Short Communication
A short communication is a report on a single subject, which should be concise but definitive. The scope of this section is intended to be wide and to encompass methodology and experimental data on subjects of interest to the readers of the Journal.
The manuscript should contain:

• abstract of no more than 250 words
• no more than 6 key words
• a running title to be used as a page heading, which should not exceed 60 letters and spaces
• manuscript main body divided into separate sections (Introduction, Material and Methods, Results and Discussion), without a separate section for conclusions
• no more than 20 references (without exceptions)
• no more than three illustrations (figures and/or tables)

Review Article
A review article should provide a synthetic and critical analysis of a relevant area and should not be merely a chronological description of the literature. A review article by investigators who have made substantial contributions to a specific area of Pharmaceutical Sciences will be published by invitation of the Editors. However, an outline of a review article may be submitted to the Editors without prior consultation. If it is judged appropriate for the Journal, the author(s) will be invited to prepare the article for peer review. The manuscript should contain:

• abstract of no more than 250 words
• no more than 6 key words
• a running title to be used as a page heading, which should not exceed 60 letters and spaces
• manuscript main body divided into sections with appropriate titles and subtitles
• no more than 90 references (without exceptions)

Mini-review Article
A mini-review is focused on a restricted part of a subject normally covered in a review article. The structure of the mini-review follows the same rules as the review.

Concepts and Comments 
The Concepts and Comments section provides a platform for readers to present ideas, theories and views.

The manuscript should contain:

• abstract of no more than 250 words
• no more than 6 key words
• a running title to be used as a page heading, which should not exceed 60 letters and spaces
• manuscript main body divided into sections with appropriate titles and subtitles
• no more than 40 references (without exceptions)

Book Reviews
Written by experts indicated by the Editors or written by the authors.

Preparing your manuscript

Cover Letter 
It is important that you include a cover letter with your manuscript. Take the time to consider why this manuscript is suitable for publication in the Brazilian Journal of Pharmaceutical Sciences. Why will your paper inspire other members of your field, and how will it drive research forward? Please explain this in your cover letter.
The cover letter should also contain the following information:

• Title of article.
• Name(s) of all author(s).
• Information of Corresponding Author (name, full address, telephone number and e-mail).

Authorship requirements 
Only people who directly contributed to the intellectual content of the paper should be listed as authors. All manuscripts must be, submitted, only, by electronic way. The confirmation of submission is sent by email for all the authors, for their agreement.
Authors should meet all of the following criteria, thereby taking public responsibility for the content of the paper:

• Conceived, planned and carried out the experiments presented in the manuscript or interpreted the data, or both.
• Wrote the paper, or reviewed successive versions.
• Approved the final version.
• Holding positions of administrative leadership, contributing patients, and collecting and assembling data, however important to the research, are not by themselves criteria for authorship. Any person who has made substantial, direct contribution to the work but cannot be considered an author should be cited in the Acknowledgment section, with permission and a description of his/her specific contribution to the research.

Text format

• The text of a manuscript can only be accepted as a Microsoft Word file created with MS Word as a "doc", "docx" or "rtf" document.
• Manuscripts should be sent in 30-36 lines, 1,5 spaced,
• Each page should contain the page number in the upper right-hand corner starting with the title page as page 1.
• Report all measurements in Système International, SI (http://physics.nist.gov/cuu/Units) and standard units where applicable
• Names of plants, animals and chemicals should be mentioned according to International Rules available.
• Names of drugs can follow the International rules (DCI) or current Brazilian rules (DCB)
• Trademarks may be mentioned only once in the text (between parenthesis and initial in capital letter)
• Do not use abbreviations in the title and limit their use in the abstract and text.
• The length of the manuscript and the number of tables and figures must be kept to a minimum.
• Ensure that all references are cited in the text.
• Generic names must be used for all drugs. Instruments may be referred to by proprietary name; the name and country of the manufacturer should be given in parenthesis.

Organization of the Manuscript
Most articles published in BJPS will be organized into the following sections:
Title, Authors, Abstract, Key words, Running Title, Author for Correspondence and email address
Introduction
Material and Methods
Results and Discussion
Acknowledgments
References
Tables with a descriptive title and footnote legends
Figures with a descriptive title, descriptive legends and uniformity in format
Continuous page numbers are required for all pages including figures. There are no specific length restrictions for the overall manuscript or individual sections. However, we urge authors to present and discuss their findings concisely. We recognize that some articles will not be best presented in our research article format. If you have a manuscript that would benefit from a different format, please contact the editors to discuss this further.

Title Page

Title - The title should be as short and informative as possible, should not contain non-standard acronyms or abbreviations, and should not exceed two printed lines.

Examples:
Freeze-drying of ampicillin solid lipid nanoparticles using mannitol as cryoprotectant
A fully validated microbiological assay for daptomycin injection and comparison to HPLC method
Pharmacokinetics, safety and tolerability of L-3-n-butylphthalide tablet after single and multiple oral administrations in healthy Chinese volunteers.

Authors and Affiliations
Full name (matched with superscript numbers identifying affiliation). Institution(s) (Department, Faculty, University, City, State, Country) of each author (in English).

Examples:
Hongmei Xia1  *  , Yongfeng Cheng2  , Yinxiang Xu3  , Zhiqing Cheng1  
1College of Pharmacy, Anhui University of Chinese Medicine, Hefei, People's Republic of China.
2School of Life Science, University of Science and Technology of China, Hefei, People's Republic of China.
3Zhaoke (Hefei) Pharmaceutical Co. Ltd., Hefei, People's Republic of China.

Abstract
Since abstracts are published separately by Information Services, they should contain sufficient hard data to be appreciated by the reader. The abstract should not exceed 250 words and should be prepared in a single paragraph.
The abstract should briefly and clearly present the objective, experimental approach, new results as quantitative data if possible, and conclusions. It should mention the techniques used without going into methodological detail and mention the most important results.
Abbreviations should be kept to a minimum and should be defined in both the Abstract and text. Please do not include any reference citations in the abstract. If the use of a reference is unavoidable, the full citation should be given within the abstract.

Key Words
A list of key words or indexing terms (no more than 6) should be included avoiding generic terms.

Running title 
This short title, to be used as a page heading, should not exceed 60 letters and spaces.

Corresponding author 
One of the authors should be designated as the corresponding author. It is the corresponding author´s responsibility to ensure that the author list is accurate and complete. If the article has been submitted on behalf of a consortium, all consortium members and affiliations should be listed in the Acknowledgments section. Provide the name and email address of the author to whom correspondence should be sent identified with an asterisk.

Introduction 
The Introduction should put the focus of the manuscript into a broader context and reflects the present state-of-art of the subject. This should state briefly and clearly the objectives of the investigation with reference to previous works. Extensive review of the literature should be avoided and substituted for references of recent review publications.

Material and Methods 
These should be described in sufficient detail that the work can be reproduced. Well-established procedures and techniques require only a citation of the original source, except when they are substantially modified. Reports of experimental studies on humans and animals must certify that the research received prior approval by the appropriate institutional review Ethics Committee.

Results and Discussion: Results must be presented clearly and concisely and in logical order. This section should provide results of all of experiments required to support the conclusions of the paper. When possible, use figures or tables to present data rather than text. Large datasets, including raw data, should be submitted as supplementary files; these are published online linked to the article. Discussion should interpret the results and assess their significance in relation to existing knowledge. Speculation not warranted by actual data should be avoided. The Discussion should spell out the major conclusions and interpretations of the work including some explanation of the significance of these conclusions.

Acknowledgments 
When appropriate, briefly acknowledge technical assistance, advice and contributions from colleagues. People who contributed to the work but do not fit the criteria for authors should be listed in the Acknowledgments section, along with their contributions. Donations of animals, cells, or reagents should also be acknowledged. You must also ensure that anyone named in the Acknowledgments agrees to being so named. Financial support for the research and fellowships should be acknowledged in this section (agency and grant number).

Figures
Figures must be submitted in high-resolution version (600 dpi).

Preparing figure files for submission
BJPS encourages authors to use figures where this will increase the clarity of an article. The use of color figures in articles is free of charge. The following guidelines must be observed when preparing figures. Failure to do so is likely to delay acceptance and publication of the article.

• Each figure of a manuscript should be submitted as a single file.
• Figures should be numbered in the order they are first mentioned in the text, and uploaded in this order.
• Figure titles and legends should be provided in the main manuscript as a List of Figures, not in the graphic file.
• The aim of the figure legend should be to describe the key messages of the figure, but the figure should also be discussed in the text.
• An enlarged version of the figure and its full legend will often be viewed in a separate window online, and it should be possible for a reader to understand the figure without moving back and forth between this window and the relevant parts of the text.
• The legend itself should be succinct, while still explaining all symbols and abbreviations. Avoid lengthy descriptions of methods. Statistical information should be given as well as the statistical tests used.
• Arrows or letters should be used in the figure and explained in the legend to identify important structures.
• Figures with multiple panels should use capital letters A, B, C, etc. to identify the panels.
• Each figure should be closely cropped to minimize the amount of white space surrounding the illustration. Cropping figures improves accuracy when placing the figure in combination with other elements, when the accepted manuscript is prepared for publication.
• Individual figure files should not exceed 5 MB. If a suitable format is chosen, this file size is adequate for extremely high quality figures.

Please note that it is the responsibility of the author(s) to obtain permission from the copyright holder to reproduce figures (or tables) that have previously been published elsewhere. In order for all figures to be open-access, authors must have permission from the rights holder if they wish to include images that have been published elsewhere in non-open-access journals. Permission should be indicated in the figure legend, and the original source included in the reference list;

Supported file type

The following file format can be accepted: TIFF (suitable for images) or JPEG with 600 dpi, and Word file for the manuscript.

Tables

• Tables must be submitted in Word (.doc) or Excel (.xls), not as an image.
• Tables must be numbered consecutively with Roman numerals in the text.
• Tables must have a concise and descriptive title.
• All explanatory information should be given in a footnote below the table. Footnotes should be used to explain abbreviations and provide statistical information, including statistical tests used.
• All abbreviations must be defined in this footnote, even if they are explained in the text.
• Tables must be understandable without referring to the text.
• Tables occupying more than one printed page should be avoided, if possible.
• Vertical and diagonal lines should not be used in tables; instead, indentation and vertical or horizontal space should be used to group data.

References 
References should be prepared and listed according to Vancouver standard reference style. Entries should be arranged in alphabetical order by author at the end of the paper. All authors’ names should be given. Accuracy and completeness of reference data is the responsibility of the authors. 
Only published references should be included in the reference list. Meeting abstracts, conference talks, or papers that have been submitted but not yet accepted should not be cited. Limited citation of unpublished work should be included in the body of the text only. All personal communications should be supported by a letter from the relevant authors.
References should be cited in the text by the authors’ names, with only the first letter in capital letter followed by the year of publication. For more than three authors, the first has to be cited followed by the expression et al. (in italic). Small letters close to the year must differentiate references of the same authors and year of publication. 
Examples: 
(Fujisawa, Atsumi, Kadoma, 1989)
(Aviral et al., 2009)
(Dodu, Rotari, Vazques, 2012)
(Liu et al., 2011a)
(Liu et al., 2011b)

Please use the following style for the reference list:

Published Papers. First 6 authors followed by et al., Title, Journal (abbreviation in italic), Year, Volume, Complete Pages. 
Abe T, Fukushima N, Brune K, Boehm C, Sato N, Matsubayashi H, et al. Genome‐Wide allelotypes of familial pancreatic adenocarcinomas and familial and sporadic intraductal papillary muninous neoplasms. Clin Cancer Res. 2007;13(20):6019‐25.
Ali A, Iqbal F, Taj A, Iqbal Z, Amin MJ, Iqbal QZ. Prevalence of microvascular complications in newly diagnosed patients with Type 2 diabetes. Pak J Med Sci. 2013,29(4): 899-902. 
Calvo A, Gimenez MJ. Ex Vivo Serum Activity (Killing Rates) After Gemifloxacin 320 mg Versus Trovafloxacin 200 mg Single Doses Against Ciprofloxacin-Susceptible and -Resistant Streptococcus pneumoniae. Int J Antimicr Ag. 2007;20:144-6. 
Lammers AE, Hislop AA, Flynn Y, Haworth SG. The 6-minute walk test: normal values for children of 4-11 years of age. Arch Dis Child. 2008;93:464-468. 
Zhang Q, Malik P, Pandey D, Gupta S, Jagnandan D, Belin de CE, et al. Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidase. Arterioscler Thromb Vasc Biol. 2008;28:1627-1633.

Article accepted for publication but not yet published. First 6 authors followed by et al., Title, Journal (abbreviation in italic), Year of expected publication, (in press) at the end of the citation. 
Janiszewski M, Lopes LR, Carmo AO, Pedro MA, Brandes RP, Santos CXC, et al. Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells. J Biol Chem. 2005 (in press).

Internet Communication. Ensure that URLs are active and available. Provide DOI, if available. 

Brasil. Ministério da Saúde, Secretaria de Vigilância em Saúde. Leishmaniose visceral
grave: normas e condutas [Internet]. Brasília (DF): Ministério da Saúde, 2006. [citado
2008 Jan 7]. 60 p. (Série A. Normas e Manuais Técnicos). Disponível em:
http://dtr2001.saude.gov.br/editora/produtos/livros/pdf/06_0072_M.pdf

CAPES Statistics. [citad 2006 Mar 16]. Available from: http://www.capes.gov.br/capes/portal.

Developmental toxicology. [citad 2015 Apr 10]. Available from: http://www.devtox.org/nomenclature/organ.php. 

Book, Whole. Authors, Book title, Edition, City, Publisher, Year. 
Hewitt W. Microbiological assay for pharmaceutical analysis: a rational approach. Boca Raton: CRC Press; 2003.
Jenkins PF. Making sense of the chest x-ray: a hands-on guide. New York: Oxford University Press; 2005. 194 p. 
Milech A, et al., Oliveira JEP, Vencio S, organizadores. Diretrizes da Sociedade Brasileira de Diabetes. São Paulo: A.C. Farmacêutica;2016.

Book, Chapter. Authors, Chapter Title, Editors, Book title, Edition, City, Publisher, Year, Pages of citation.
Beizer JL, Timiras ML. Pharmacology and drug management in the elderly. In: Timiras PS, editor. Physiological basis of aging and geriatrics. 2nd ed. Boca Raton: CRC Press; 1994. p. 279-84.
Rojko JL, Hardy WD Jr. Feline leukemia virus and other retroviruses. In: Sherding RG, editor. The cat: diseases and clinical management. New York: Churchill Livingstone; 1989. p. 229-332.

Report

World Health Organization. WHO. Department of Mental Health and Substance Abuse. Mental health atlas 2005. Geneva: World Health Organization; 2005. 409 p.

World Health Organization. WHO. Working to overcome the global impact of neglected tropical diseases, First WHO report on neglected tropical diseases. Geneva, Switzerland: WHO Press; 2010.

Thesis and Dissertations

Joselevitch C. Visão no ultravioleta em Carassius auratus (Ostariophysi, Cypriformes, Cyprinidae): estudo eletrofisiológico do sistema cone - células horizontais. [Master's dissertation]. São Paulo: Instituto de Psicologia, USP; 1999.

Marcolongo R. Dissolução de medicamentos: fundamentos, aplicações, aspectos regulatórios e perspectivas na área farmacêutica. [dissertação]. São Paulo: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas; 2003.

Laws 
Agência Nacional de Vigilância Sanitária (Brasil). Resolução nº. 259, de 20 de setembro de 2002. Regulamento Técnico para Rotulagem de Alimentos Embalados. Diário Oficial da União 23 set 2002; Seção 1.

Conference, Symposium Proceedings. Cite papers only from published proceedings.

Hejzlar RM, Diogo PA. The use of water quality modelling for optimizing operation of a drinking water reservoir. In: Proceedings of the International Conference Fluid Mechanics and Hydrology. 1999 Jun 23-26; Prague. Prague: Institute of Hydrodynamics AS CR; 1999. p 475-482.

Proceedings of the 10th annual meeting of the Canadian Society for Pharmaceutical
Sciences. J Pharm Pharm Sci. 2007 Dec 3;10(4):1s-186s.

Audiovisual Material 
Physician's Desk Reference (PDR). Release 2003.1AX. [CD-ROM]. Montvale: Thomson PDR; 2003.

Computer Program
Dean AG, Dean JA, Coulombier D, Brendel KA, Smith DC, Burton AH, et al. Epi info, version 6.04: a word processing database and statistics program for public health on IBM-compatible microcomputers. [Computer program]. Atlanta: Centers of Disease Control and Prevention; 1998.

Patent
Larsen CE, Trip R, Johnson CR. Methods for procedures related to the electrophysiology of the heart. Patent No. 5.529.067. Novoste Corporation; 1995.

Submission should be sent electronically through the ScholarOne system (mc04.manuscriptcentral.com/bjps-scielo).

If you need further assistance, please contact the Journal Staff (bjps@usp.br).

There is no charges for article’s submissions, evaluations and publication.

Additional informations:
Brazilian Journal of Pharmaceutical Sciences
Divisão de Biblioteca e Documentação do Conjunto das Químicas/USP
Serviço de Publicações e Circulação
Av. Prof. Lineu Prestes, 950
05508-000 - São Paulo - SP - Brasil 
Tel: +55 11 3091.2314
E-mail: bjps@usp.br