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Mucoadhesive drug delivery systems


 
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1. Title Title of document Mucoadhesive drug delivery systems
 
2. Creator Author's name, affiliation, country Flávia Chiva Carvalho; São Paulo State University; School of Pharmaceutical Sciences
 
2. Creator Author's name, affiliation, country Marcos Luciano Bruschi; State University of Maringá; Department of Pharmacy
 
2. Creator Author's name, affiliation, country Raul Cesar Evangelista; São Paulo State University; School of Pharmaceutical Sciences,; Department of Drugs and Pharmaceuticals
 
2. Creator Author's name, affiliation, country Maria Palmira Daflon Gremião; São Paulo State University; School of Pharmaceutical Sciences,; Department of Drugs and Pharmaceuticals
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) Mucoadhesion;Bioadhesion;Mucoadhesive systems;Drugs^i1^sdeliv
 
4. Description Abstract Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
 
5. Publisher Organizing agency, location Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2010-03-01
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://www.revistas.usp.br/bjps/article/view/10749
 
10. Identifier Digital Object Identifier (DOI) http://dx.doi.org/10.1590/S1984-82502010000100002
 
11. Source Title; vol., no. (year) Brazilian Journal of Pharmaceutical Sciences (Impresso); Vol 46, No 1 (2010)
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2017 Brazilian Journal of Pharmaceutical Sciences (Impresso)
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