Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives
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| 1. | Title | Title of document | Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives |
| 2. | Creator | Author's name, affiliation, country | Isabela Jacob Moro; São Paulo State University; School of Pharmaceutical Sciences; Laboratory of Pharmacognosy; Brazil |
| 2. | Creator | Author's name, affiliation, country | Gabrielle Demmany Gualberto Alexandre Gondo; São Paulo State University; School of Pharmaceutical Sciences; Laboratory of Pharmacognosy; Brazil |
| 2. | Creator | Author's name, affiliation, country | Elaíse Gonçalves Pierri; São Paulo State University; School of Pharmaceutical Sciences; Laboratory of Pharmacognosy; Brazil |
| 2. | Creator | Author's name, affiliation, country | Rosemeire Cristina Linharis Rodrigues Pietro; São Paulo State University; School of Pharmaceutical Sciences; Laboratory of Biotechnology; Brazil |
| 2. | Creator | Author's name, affiliation, country | Christiane Pienna Soares; São Paulo State University; School of Pharmaceutical Sciences; Laboratory of Cell Biology; Brazil |
| 2. | Creator | Author's name, affiliation, country | Damião Pergentino de Sousa; Univ Federal da Paraíba; Health Sciences Center; Departament of Pharmaceutical Sciences; Brazil |
| 2. | Creator | Author's name, affiliation, country | André Gonzaga dos Santos; São Paulo State University; School of Pharmaceutical Sciences; Laboratory of Pharmacognosy; Brazil |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Carvone/antimicrobial activity; Carvone/antifungal activity; Carvone /cytotoxicity; Carvone/chemoprevention |
| 4. | Description | Abstract | Considering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β-epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. The antifungal activity (MIC and MFC) were evaluated against Candida parapsilosis, C. tropicalis, C. krusei and C. albicans and the antibacterial activity (MIC and MBC) against Escherichia coli and Staphylococcus aureus. The cytotoxicity assays were performed with human cancer cell lines HepG-2 and SiHa and the normal strain MRC-5 through sulphorrodamine B assay. Chemoprevention was evaluated through quinone reductase assay. Our results showed no cytotoxicity on tumor and normal cell lines and no induction of the quinone reductase enzyme. C- and HC- presented activity against E. coli. All compounds presented weak antifungal activity against C. tropicalis and C. parapsilosis. EP and C+ showed moderate activity against C. krusei. Results suggest the potential use of carvones and its derivatives as antifungal agents against Candida yeasts. The absence of cytotoxicity in cell lines indicates safety in the use of these compounds. |
| 5. | Publisher | Organizing agency, location | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 2017-01-01 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://www.revistas.usp.br/bjps/article/view/142561 |
| 10. | Identifier | Digital Object Identifier (DOI) | http://dx.doi.org/10.1590/s2175-97902017000400076 |
| 11. | Source | Title; vol., no. (year) | Brazilian Journal of Pharmaceutical Sciences (Impresso); Vol 53, No 4 (2017) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) This work is licensed under a Creative Commons Attribution 4.0 International License. |