The radiation protection role of heparin-SOD conjugate in irradiated mice
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| 1. | Title | Title of document | The radiation protection role of heparin-SOD conjugate in irradiated mice |
| 2. | Creator | Author's name, affiliation, country | Chuanqing Zhong; Shandong Jianzhu University; School of Municipal and Environmental Engineering; China |
| 2. | Creator | Author's name, affiliation, country | Xiaojing Huang; Henan Provincial People’s Hospital; Department of Pharmacy; China |
| 2. | Creator | Author's name, affiliation, country | Shu Zhang; Shandong University; School of Pharmaceutical Science; Institute of Biochemical and Biotechnological Drugs; China |
| 2. | Creator | Author's name, affiliation, country | Yanna Cheng; Shandong University; School of Pharmaceutical Science; Institute of Biochemical and Biotechnological Drugs; China |
| 2. | Creator | Author's name, affiliation, country | Guangxiang Cao; Shandong Medicinal Biotechnology Centre; China |
| 2. | Creator | Author's name, affiliation, country | Fengshan Wang; Shandong University; School of Pharmaceutical Science; Institute of Biochemical and Biotechnological Drugs; China |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Heparin-superoxide dismutase conjugate; Radiation-induced damage; Oxidative stress injury |
| 4. | Description | Abstract | Heparin-SOD conjugate (Hep-SOD) was prepared by modifying Cu,Zn-SOD with heparin. An acute radiation-induced mouse injury model was constructed to study the radiation protection effects of Hep-SOD conjugate. Fifty-six mice were randomly divided into seven groups: (I) normal control group; (II) irradiated control group; (III) positive control group (amifostine group, 300 mg/kg); (IV) SOD group (35000 U/kg); (V) high dosage of Hep-SOD group (70000 U/kg); (VI) medium dosage of Hep-SOD group (35000 U/kg); (VII) low dosage of Hep-SOD group (17500 U/kg). Drugs were intraperitoneally injected into each mouse 1 h before radiation except for the normal control group. All the irradiated groups were irradiated with 6 Gy. Organ indices, haematopoietic function indices, peripheral blood cells, liver function test, oxidative stress state and pathological observation were detected to study the effects of Hep-SOD on irradiated mice. Results showed that bone marrow suppression of irradiated mice could be reduced when treated by Hep-SOD before radiation. Oxidative stress detection and pathological observation of the liver and intestine showed that the damage caused by radiation was relieved when mice were treated with Hep-SOD before radiation. This study shows a new direction to prevent organisms from the damage caused by radiation. |
| 5. | Publisher | Organizing agency, location | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 2017-01-01 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://www.revistas.usp.br/bjps/article/view/144065 |
| 10. | Identifier | Digital Object Identifier (DOI) | http://dx.doi.org/10.1590/s2175-97902017000417081 |
| 11. | Source | Title; vol., no. (year) | Brazilian Journal of Pharmaceutical Sciences (Impresso); Vol 53, No 4 (2017) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) This work is licensed under a Creative Commons Attribution 4.0 International License. |