Effect of alcoholic beverages on progeny and reproduction of mice
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Effect of alcoholic beverages on progeny and reproduction of mice |
| 2. | Creator | Author's name, affiliation, country | Fernanda Dias Figueiro; Londrina State University; Department of General Biology; Brazil |
| 2. | Creator | Author's name, affiliation, country | Ana Clara Cerato Bispo; Londrina State University; Department of General Biology; Brazil |
| 2. | Creator | Author's name, affiliation, country | Karla Lorena Guarido; Londrina State University; Department of General Biology; Brazil |
| 2. | Creator | Author's name, affiliation, country | Priscila Marianno; Londrina State University; Department of General Biology; Brazil |
| 2. | Creator | Author's name, affiliation, country | Gabriel de Araújo Costa; Londrina State University; Department of General Biology; Brazil |
| 2. | Creator | Author's name, affiliation, country | Helena Kaminami Morimoto; Londrina State University; Department of Pathology, Clinical and Toxicological Analysis; Brazil |
| 2. | Creator | Author's name, affiliation, country | Maria José Sparça Salles; Londrina State University; Department of General Biology; Brazil |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Alcoholic beverages/analysis; Wine/adverse effects; Beer/adverse effects; Cachaça/adverse effects; Reproduction/drugs effects |
| 4. | Description | Abstract | Alcohol is the most commonly consumed substance in the world. The objective of this study was to evaluate the influence of alcoholic beverages on male reproduction and possible alterations in their offspring. The mice were divided into 4 groups: beer, wine, cachaça (a type of sugarcane rum), with ethanol concentrations of 1.9 g/kg, and control group treated with PBS. The treatment period was 35 days. The animals which received cachaça, demonstrated significant weight loss in the testes and epididymis. The alcoholic beverages promoted significant testosterone level and fertilization index diminution, and morphological alterations in the spermatozoa. The beer group presented decreased implantation sites and a high frequency of dominant lethal. The number of reabsorptions in the wine group was increased. The fermented beverages presented higher potential to induce visceral malformations, while the cachaça caused fetal skeletal malformations. The cachaça treated group presented a negative impact on semen quality and fertilization potential. The treatment with different alcoholic beverages, during spermatogenesis, demonstrated contrasting degrees of induction of toxic effects, interfering in a general aspect in male reproductive performance, fetal viability during intrauterine life, and birth defects. From the data, it is possible to infer that the distillated beverage caused more harmful effects to reproduction in this study. |
| 5. | Publisher | Organizing agency, location | Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (YYYY-MM-DD) | 2017-01-01 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://www.revistas.usp.br/bjps/article/view/144066 |
| 10. | Identifier | Digital Object Identifier (DOI) | http://dx.doi.org/10.1590/s2175-97902017000417141 |
| 11. | Source | Title; vol., no. (year) | Brazilian Journal of Pharmaceutical Sciences (Impresso); Vol 53, No 4 (2017) |
| 12. | Language | English=en | en |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) This work is licensed under a Creative Commons Attribution 4.0 International License. |