Effects of the endectocid ivermectin (Ivomec(r) 1% injection) on pregnants females wistar rats

Authors

  • Vanessa Maraschin Möller Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Departamento de Farmacologia, Porto Alegre, RS
  • Eliane Dallegrave Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Departamento de Farmacologia, Porto Alegre, RS
  • Ricardo Coelho Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Departamento de Farmacologia, Porto Alegre, RS
  • Janaína Pereira Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Departamento de Farmacologia, Porto Alegre, RS
  • Augusto Langeloh Universidade Federal do Rio Grande do Sul, Instituto de Ciências Básicas da Saúde, Departamento de Farmacologia, Porto Alegre, RS

DOI:

https://doi.org/10.1590/S1413-95962003000500003

Keywords:

Ivermectin, Toxicity

Abstract

In order to evaluate the possible effect of ivermectin used on pregnant animals, Wistar rats were treated orally on sixth pregnancy day, with dosage of 20 and 60 times higher than therapeutic dosage used to treat scabiosis in dogs and cats. During all pregnant period, body weight, water and pellet food consuption of dams were determined. The dams were sacrificed at term for the evaluation of maternal and fetal parameters. The numbers of corporea lutea, post implantation loss and living and death fetuses were recorded. Also the organs of dams were removed, weighted and histopatologically examined. Fetuses were weighted, sexed, examined for external macroscopic malformations. Results showed absence of systemic and reproductive toxicity. It is concluded that ivermectin is no toxic to the dams and fetus, when administered in the beginning of organogenic period.

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Published

2003-01-01

Issue

Vol. 40 No. 5 (2003)

Section

UNDEFINIED

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Möller VM, Dallegrave E, Coelho R, Pereira J, Langeloh A. Effects of the endectocid ivermectin (Ivomec(r) 1% injection) on pregnants females wistar rats. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2003 Jan. 1 [cited 2024 Apr. 19];40(5):328-33. Available from: https://www.revistas.usp.br/bjvras/article/view/11308