A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads

Authors

  • María Victoria Nieto Farias Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil, Laboratorio de Virología
  • María Eugenia Caffaro Instituto Nacional de Tecnología Agropecuaria, Centro de Investigación en Ciencias Veterinarias y Agronómicas, Instituto de Genética “Edwald A. Favret”
  • Pamela Anahí Lendez Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil, Laboratorio de Virología
  • Juan Passucci Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Área de Epidemiología
  • Mario Poli Instituto Nacional de Tecnología Agropecuaria, Centro de Investigación en Ciencias Veterinarias y Agronómicas, Instituto de Genética “Edwald A. Favret”
  • María Carolina Ceriani Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil, Laboratorio de Virología
  • Guillermina Laura Dolcini Universidad Nacional del Centro de la Provincia de Buenos Aires, Facultad de Ciencias Veterinarias, Centro de Investigación Veterinaria de Tandil, Laboratorio de Virología

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2017.123769

Keywords:

BLV, Proviral load, BoLA DRB3 polymorphism

Abstract

Bovine leukemia virus (BLV) is associated with the most common neoplastic disease of cattle. BLV has a silent dissemination in the herd due to infected cell exchange, thus the concentration of BLV-infected cells in blood should play a major role in the success of viral transmission. Genes from Bovine leukocyte antigen (BoLA), the MHC system of cattle, are associated with genetic resistance and susceptibility to a wide range of diseases, and also with production traits. Some BoLA DRB3.2 allele polymorphisms in Holstein cattle have been associated with resistance or susceptibility to BLV-disease development, or with proviral load (PVL). This investigation studied 107 BLV-infected Argentinean Holstein dairy cows, all of them belonging to one herd. PVL was analysed by qPCR and animals were classified as high proviral load (HPVL, N = 88) and low proviral load (LPVL, N = 19), and BoLA DRB3.2 alleles were genotyped. Alleles BoLA DRB3.2*1501 and *1201 were significantly associated with HPVL (p = 0.0230 and p = 0.0111 respectively), while allele BoLA DRB3.2*0201 was significantly associated with LPVL (p = 0.0030). The present study aims at contributing to the knowledge of the association between BoLA polymorphism and development of a BLV infection profile. Genes that best explain the PVL in this population resulted BoLA DRB3.2*0201 (as a protection factor) and *1501 (as a risk factor). Allelic differences may play an important role in the development of effective immune responses. A better understanding of how BoLA polymorphism contributes to these responses and the establishment of a BLV status is desirable to schedule and evaluate control measures.

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Published

2017-11-24

How to Cite

Farias, M. V. N., Caffaro, M. E., Lendez, P. A., Passucci, J., Poli, M., Ceriani, M. C., & Dolcini, G. L. (2017). A novel association of BoLA DRB3 alleles in BLV infected cattle with different proviral loads. Brazilian Journal of Veterinary Research and Animal Science, 54(3), 215-224. https://doi.org/10.11606/issn.1678-4456.bjvras.2017.123769

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