Genetic characterization of the haemagglutinin gene in canine distemper virus strains from naturally infected dogs in Brazil

  • Adriana Cortez Universidade de Santo Amaro, Curso de Medicina Veterinária
  • Marcos Bryan Heinemann Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária Preventiva e Saúde Animal
  • Antônio Augusto Fonseca Junior Ministério da Agricultura Pecuária e Abastecimento, Laboratório Nacional Agropecuário de Minas Gerais
  • Luciana Fachini da Costa Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas
  • Vanessa Aparecida Feijó de Souza Complexo Educacional das Faculdades Metropolitanas Unidas
  • Jane Megid Universidade Estadual Paulista “Júlio de Mesquita Filho”, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Higiene Veterinária e Saúde Pública
Keywords: Brazil, South America, Canine distemper virus, Haemagglutinin (H) gene, Phylogenetic analysis

Abstract

Canine distemper is one of the major infectious diseases in dogs and wild animals, resulting in high morbidity and mortality. The H gene has the greatest genetic variability among the genes encoded by the canine distemper virus (CDV) genome, and it has been used to characterise field samples, allowing the identification of specific lineages. Variation in the H gene can allow the virus to evade recognition by vaccine-induced antibodies, resulting in vaccine failure. The purpose of this study was to characterise H gene in CDV strains from naturally infected dogs in the state of São Paulo. The phylogenetic analysis revealed that Brazilian CDV strains were genetically related to the circulating CDV strains in Uruguay, Argentina, and Europe. We found no evidence of South America 2 and 3 CDV lineages circulating in Brazilian dogs. The degree of genetic divergence between wild Brazilian CDV strains and vaccine strains may suggest the possibility of vaccine failures and consequently the occurrence of canine distemper outbreaks.

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Published
2017-12-31
How to Cite
Cortez, A., Heinemann, M., Fonseca Junior, A. A., Costa, L., Souza, V. A., & Megid, J. (2017). Genetic characterization of the haemagglutinin gene in canine distemper virus strains from naturally infected dogs in Brazil. Brazilian Journal of Veterinary Research and Animal Science, 54(4), 445-449. https://doi.org/10.11606/issn.1678-4456.bjvras.2017.133315