Serological survey of leptospirosis, brucellosis, and lentivirus in herds of small ruminants in Recôncavo Baiano, Bahia, Brazil

Authors

  • Rodrigo Rezende Mires de Carvalho Universidade Federal da Bahia, Programa de Pós-graduação em Ciência Animal nos Trópicos
  • Lucas Nogueira Paz Universidade Federal da Bahia, Programa de Pós-graduação em Ciência Animal nos Trópicos
  • Carla Silva Dias Universidade Federal da Bahia, Programa de Pós-graduação em Ciência Animal nos Trópicos
  • Giselle Almeida Nocera Instituto de Tecnologia do Paraná, Diretoria de Produção
  • Augusto José Pereira de Mesquita Agência de Defesa Agropecuária da Bahia, Laboratório de Defesa e Saúde Animal
  • Melissa Hanzen Pinna Universidade Federal da Bahia, Departamento de Medicina Veterinária Preventiva e Produção Animal, Laboratório de Bacterioses https://orcid.org/0000-0002-2293-9532

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2021.180290

Keywords:

Diagnosis, Reproductive changes, Leptospira spp. Sorologia, Caprine arthritis-encephalitis, Maedi-Visna, Brucella ovis

Abstract

A serological survey was carried out to assess the frequency of leptospirosis, small ruminants lentivirus (SRLV), and brucellosis in small ruminant herds in the Recôncavo Baiano, State of Bahia, Brazil, from February to December 2017. In four goat herds, 125 animals were tested for SRLV and leptospirosis, while in five sheep herds, 378 animals were tested for leptospirosis, brucellosis, and SRLV. Regarding leptospirosis, MAT detected 80% of goats and 15.34% of sheep seroreactive. Reactivity was most frequent to serogroups Autumnalis and Grippotyphosa in goats and sheep, respectively. Regarding SRLV, 8.8% of goats and 0.79% of sheep were reactive. Search for anti-B. ovis antibodies revealed 0.52% reactivity. In sheep, three animals showed simultaneous seroreactivity for SRLV and leptospirosis, while one animal had a serological response for brucellosis and leptospirosis. In goats, simultaneous seroreactivity for SRLV and leptospirosis was observed in only one animal. Leptospirosis was the most frequent of the three infectious diseases in investigated herds.

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References

Adler B, de la Peña Moctezuma A. Leptospira and leptospirosis. Vet Microbiol. 2010;140(3-4):287-96. http://dx.doi.org/10.1016/j.vetmic.2009.03.012. PMid:19345023.

Agudelo-Flórez P, Londono AF, Quiroz VH, Ángel JC, Moreno N, Loaiza ET, Muñoz LF, Rodas JD. Prevalence of Leptospira spp. in urban rodents from a groceries trade center of Medellin, Colombia. Am J Trop Med Hyg. 2009;81(5):906-10. http://dx.doi.org/10.4269/ajtmh.2009.09-0195. PMid:19861630.

Almeida DS, Paz LN, de Oliveira DS, Silva DN, Ristow P, Hamond C, Costa F, Portela RW, Estrela-Lima A, Pinna MH. Investigation of chronic infection by Leptospira spp. in asymptomatic sheep slaughtered in slaughterhouse. PLoS One. 2019;14(5):e0217391. http://dx.doi.org/10.1371/journal.pone.0217391. PMid:31120961.

Alves CJ, de Figueiredo SM, de Azevedo SS, Clementino IJ, Keid LB, Vasconcellos SA, de Sousa Américo Batista C, Rocha VC, Higino SS. Detection of Brucella ovis in ovine from Paraíba State, in the Northeast region of Brazil. Braz J Microbiol. 2010;41(2):365-7. http://dx.doi.org/10.1590/S1517-83822010000200016. PMid:24031505.

Araújo-Neto JO, Alves CJ, Azevedo SS, Silva MLCR, Batista CDSA. Soroprevalência da leptospirose em caprinos da microrregião do Seridó Oriental, Estado do Rio Grande do Norte, Brasil, e pesquisa de fatores de risco. Braz J Vet Res Anim Sci. 2010;47(2):144-8. http://dx.doi.org/10.11606/issn.1678-4456.bjvras.2010.26839.

Assenga JA, Matemba LE, Muller SK, Mhamphi GG, Kazwala RR. Predominant leptospiral serogroups circulating among humans, livestock and wildlife in Katavi-Rukwa ecosystem, Tanzania. PLoS Negl Trop Dis. 2015;9(3):e0003607. http://dx.doi.org/10.1371/journal.pntd.0003607. PMid:25806825.

Bandeira DA, de Castro RS, Azevedo EO, de Souza Seixas Melo L, de Melo CB. Seroprevalence of caprine arthritis–encephalitis virus in goats in the Cariri region, Paraiba state, Brazil. Vet J. 2009;180(3):399-401. http://dx.doi.org/10.1016/j.tvjl.2008.02.007. PMid:18675568.

Campos ÂP, Miranda DFH, Rodrigues HWS, da Silva Carneiro Lustosa M, Martins GHC, Mineiro ALBB, Castro V, Azevedo SS, de Sousa Silva SMM. Seroprevalence and risk factors for leptospirosis in cattle, sheep, and goats at consorted rearing from the State of Piauí, northeastern Brazil. Trop Anim Health Prod. 2017;49(5):899-907. http://dx.doi.org/10.1007/s11250-017-1255-2. PMid:28357645.

Chen X, Xie X, Wu D, Zhang S, Zhang W, Cao Y. The pre-activated immune response induced by LPS protects host from leptospirosis. PLoS One. 2020;15(11):e0242742. https://doi.org/10.1371/journal.pone.0242742.

Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI. Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis. 2015;9(9):1-19.

Dorjee S, Heur C, Jackson R, West DM, Collins-Emerson JM, Midwinter AC, Ridler AL. Prevalence of pathogenic Leptospira spp. in sheep in a sheep-only abattoir in New Zealand. New Zeal Vet J. 2008;56(4):164-70.

Dorneles EMS, Guimarães AS, Gouveia AMG, Coura FM, Carmo FB, Pauletti RB, Azevedo V, Lilenbaum W, Vitor RWA, Pinheiro RR, Ferreira ACR, Dasso MG, Lage AP, Heinemann MB. Seroprevalence of Brucella ovis-epididymitis, smooth-Brucella, leptospirosis, toxoplasmosis, and Maedi-Visna in sheep slaughtered in Minas Gerais State, Brazil. Braz J Vet Res Anim Sci. 2020;57(2):164278-164278. http://dx.doi.org/10.11606/issn.1678-4456.bjvras.2020.164278.

Elderbrook M, Schumaker B, Cornish T, Peck D, Sondgeroth K. Seroprevalence and risk factors of Brucella ovis in domestic sheep in Wyoming, USA. BMC Vet Res. 2019;15(1):246. http://dx.doi.org/10.1186/s12917-019-1995-5. PMid:31307483.

Ellis WA. Animal leptospirosis. Curr Top Microbiol Immunol. 2015;387:99-137. http://dx.doi.org/10.1007/978-3-662-45059-8_6. PMid:25388134.

Faine S, Adler B, Bolin C, Perolat P. Leptospira and leptospirosis. Melbourne: Australia MediSci; 2000.

Higino SSS, Santos FA, Costa DF, Santos CSAB, Silva MLCR, Alves CJ, Azevedo SS. Flock-level risk factors associated with leptospirosis in dairy goats in a semiarid region of Northeastern Brazil. Prev Vet Med. 2013;109(1-2):158-61. http://dx.doi.org/10.1016/j.prevetmed.2012.09.005. PMid:23031326.

Instituto Brasileiro de Geografia e Estatística. Sistema IBGE de Recuperação Automática – SIDRA [Internet]. Rio de Janeiro: IBGE; 2017 [cited 2020 Dec 22]. Available from: from: www.sidra.ibge.gov.br.

Junkuszew A, Dudko P, Bojar W, Olech M, Osiński Z, Gruszecki TM, Kania MG, Kuźmak J, Czerski G. Risk factors associated with small ruminant lentivirus infection in eastern Poland sheep flocks. Prev Vet Med. 2016;127:44-9. http://dx.doi.org/10.1016/j.prevetmed.2016.03.011. PMid:27094139.

Larruskain A, Jugo BM. Retroviral infections in sheep and goats: small ruminant lentiviruses and host interaction. Viruses. 2013;5(8):2043-61. http://dx.doi.org/10.3390/v5082043.

Li JY, Liu Y, Gao XX, Gao X, Cai H. TLR2 and TLR4 signaling pathways are required for recombinant Brucella abortus BCSP31-induced cytokine production, functional upregulation of mouse macrophages, and the Th1 immune response in vivo and in vitro. Cell Mol Immunol. 2014;11(5):477-94. http://dx.doi.org/10.1038/cmi.2014.28. PMid:24769793.

Lilenbaum W, de Souza GN, Ristow P, Moreira MC, Fráguas S, Cardoso VS, Oelemann WM. A serological study on Brucella abortus, caprine arthritis–encephalitis virus and Leptospira in dairy goats in Rio de Janeiro, Brazil. Vet J. 2007;173(2):408-12. http://dx.doi.org/10.1016/j.tvjl.2005.12.003. PMid:16455276.

Lilenbaum W, Varges R, Medeiros L, Cordeiro AG, Cavalcanti A, Souza GN, Richtzenhain L, Vasconcellos SA. Risk factors associated with leptospirosis in dairy goats under tropical conditions in Brazil. Res Vet Sci. 2008;84(1):14-7. http://dx.doi.org/10.1016/j.rvsc.2007.03.011. PMid:17543359.

Lilenbaum W, Varges R, Ristow P, Cortez A, Souza SO, Richtzenhain JL, Vasconcellos AS. Identification of Leptospira spp. carriers among seroreactive goats and sheep by polymerase chain reaction. Res Vet Sci. 2009;87(1):16-9. http://dx.doi.org/10.1016/j.rvsc.2008.12.014. PMid:19232418.

Lima CCV, Costa JN, Souza TS, Martinez P, Costa AO No, Anunciação AVM, Almeida MGÁR, Araújo BR, Pinheiro RR. Inquérito soroepidemiológico do lentivírus caprino e perfil das criações de caprinos na região do Baixo Médio São Francisco (BA). Arq Inst Biol. 2013;80(3):288-96. http://dx.doi.org/10.1590/S1808-16572013000300005.

Magalhães KA, Martins EC, Holanda ZF Fo, Lucena CC. Pesquisa Pecuária Municipal 2017: efetivo dos rebanhos caprinos e ovinos. Sobral: Embrapa Caprinos e Ovinos; 2018. (Boletim do Centro de Inteligência e Mercado de Caprinos e Ovinos, No. 5).

Martinez PM, Costa JN, De Souza TS, De Lima CCV, Costa Neto AO, Pinheiro RR. Prevalência sorológica da Maedi-Visna em rebanhos ovinos damicrorregião de Juazeiro-Bahia por meio do teste de imunodifusão em gel de ágar. Ci Anim Bras. 2011;12(2):322-329. http://dx.doi.org/10.5216/cab.v12i2.4454.

Martins G, Lilenbaum W. Leptospirosis in sheep and goats under tropical conditions. Trop Anim Health Prod. 2014;46(1):11-7. http://dx.doi.org/10.1007/s11250-013-0480-6.

Martins G, Penna B, Hamond C, Leite CR, Silva A, Ferreira A, Brandão F, Oliveira F, Lilenbaum W. Leptospirosis as the most frequent infectious disease impairing productivity in small ruminants in Rio de Janeiro, Brazil. Trop Anim Health Prod. 2012;44(4):773-7. http://dx.doi.org/10.1007/s11250-011-9964-4. PMid:21898182.

Melo EX, Almeida EC, Mendonça KMN, Nascimento SA, Silva JCR, Marvulo MFV, Rizzo H, Castro RS. Seroprevalence small ruminant lentiviruses in the state of Pernambuco slaughterhouses, Brazil. Arq Inst Biol. 2016;83:e0462015. http://dx.doi.org/10.1590/1808-1657000462015.

Pappas G, Papadimitriou P, Siozopoulou V, Christou L, Akritidis N. The globalization of leptospirosis: worldwide incidence trends. Inter. Int J Infect Dis. 2008;12(4):351-7. http://dx.doi.org/10.1016/j.ijid.2007.09.011. PMid:18055245.

Pinna MH, Martins G, Loureiro AP, Lilenbaum W. Detection of bovine carriers of Leptospira by serological, bacteriological, and molecular tools. Trop Anim Health Prod. 2018;50(4):883-8. http://dx.doi.org/10.1007/s11250-018-1512-z. PMid:29349716.

Ribeiro KÁ, de Alencar CMM. Desenvolvimento territorial e a cadeia produtiva da caprinovinocultura no semiárido baiano: o caso do município de Juazeiro-BA. Rev Bras Estud Urbanos Reg. 2018;4(1):144-79. http://dx.doi.org/10.18224/baru.v4i1.6571.

Salaberry SRS, Castro V, Nassar AFC, Castro JR, Guimarães EC, Lima-Ribeiro AMC. Seroprevalence and risk factors of antibodies against Leptospira spp. in ovines from Uberlândia municipality, Minas Gerais state, Brazil. Braz J Microbiol. 2011;42(4):1427-33. http://dx.doi.org/10.1590/S1517-83822011000400026. PMid:24031773.

Santos FA, Higino SS, Azevedo SS, Costa DF, Farias AE, Alves FAL, Paulin LM, Alves CJ. Caracterização epidemiológica e fatores de risco associados à infecção por Brucella ovis em ovinos deslanados do semiárido paraibano. Pesq Vet Bras. 2013;33(4):459-63. http://dx.doi.org/10.1590/S0100-736X2013000400008.

Santos LF, Guimarães MF, Souza GO, Silva IWG, Santos JR, Azevedo SS, Labruna MB, Heinemann MB, Horta MC. Seroepidemiological survey on Leptospira spp. infection in wild and domestic mammals in two distinct areas of the semi-arid region of northeastern Brazil. Trop Anim Health Prod. 2017;49(8):1715-22. http://dx.doi.org/10.1007/s11250-017-1382-9. PMid:28861677.

Santos PJ, Lima-Ribeiro AMC, Oliveira PR, Santos MP, Ferreira Jr A, Medeiros AA, Tavares TCF. Seroprevalence and risk factors for Leptospirosis in goats in Uberlândia, Minas Gerais, Brazil. Trop Anim Health Prod. 2012;44(1):101-6. http://dx.doi.org/10.1007/s11250-011-9894-1. PMid:21647773.

Silva AF, Farias PJA, Silva MLCR, Araújo JP Jr, Malossi CD, Ullmann LS, Costa DF, Higino SSS, Azevedo SS, Alves CJ. High frequency of genital carriers of Leptospira sp. in sheep slaughtered in the semi-arid region of northeastern Brazil. Trop Anim Health Prod. 2019;51(1):43-7. http://dx.doi:10.1007/s11250-018-1657-9.

Soares PM, Gomes DO, Macedo FP, Soares MM, Lemes KR, Jaeger LH, Lilenbaum W, Lima AMC. Serological and molecular characterization of Leptospira kirschneri serogroup Grippotyphosa isolated from bovine in Brazil. Microb Pathog. 2020;138:103803. http://dx.doi.org/10.1016/j.micpath.2019.103803. PMid:31626918.

Sousa MM, Andrioli A, Pinheiro RR, Alves FSF, Santos VWS, Damasceno EM, Araújo JF, Sousa ALM, Vieira LS. An epidemiological study of caprine arthritis encephalitis virus (CAEV) in breeder goats from Northeastern Brazil. Semin Cienc Agrar. 2019;40(5):1857-66. http://dx.doi.org/10.5433/1679-0359.2019v40n5p1857.

Souza TS, Costa JN, Martinez PM, Lima CCV, Araújo BR, Costa Neto AO, Anunciação AVM, Almeida MGAR, Pinheiro RR. Inquérito soro-epidemiológico de Brucella ovis em rebanhos ovinos no semiárido baiano. Arq Inst Biol. 2012;79(2):277-81. http://dx.doi.org/10.1590/S1808-16572012000200017.

Suepaul SM, Carrington CV, Campbell M, Borde G, Adesiyun AA. Seroepidemiology of leptospirosis in livestock in Trinidad. Trop Anim Health Prod. 2011;43(2):367-75. http://dx.doi.org/10.1007/s11250-010-9698-8. PMid:20953838.

Suwancharoen D, Chaisakdanugull Y, Thanapongtharm W, Yoshida S. Serological survey of leptospirosis in livestock in Thailand. Epidemiol Infect. 2013;141(11):2269-77. http://dx.doi.org/10.1017/S0950268812002981. PMid:23308397.

Torres-Velez F, Havas KA, Spiegel K, Brown C. Transboundary animal diseases as re-emerging threats–Impact on onehealth. Semin Diagn Pathol. 2019;36(3):193-6. http://dx.doi.org/10.1053/j.semdp.2019.04.013. PMid:31053264.

World Organisation for Animal Health. Criteria for the inclusion of diseases, infections and infestations in the OIE list,Terrestrial Animal Health Code [Internet]. Paris: OIE; 2019 [cited 2020 Dec 22]. Available from: https://www.oie.int/fileadmin/Home/eng/Health_standards/tahc/current/chapitre_criteria_diseases.pdf.

World Organisation for Animal Health. Manual of Diagnostic Tests and Vaccines for Terrestrial Animals [Internet]. Paris: OIE; 2018 [cited 2020 Dec 22]. Available from: https://www.oie.int/standard-setting/terrestrial-manual/.

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Published

2021-07-27

How to Cite

Carvalho, R. R. M. de, Paz, L. N. ., Dias, C. S., Nocera, G. A., Mesquita, A. J. P. de, & Pinna, M. H. . (2021). Serological survey of leptospirosis, brucellosis, and lentivirus in herds of small ruminants in Recôncavo Baiano, Bahia, Brazil. Brazilian Journal of Veterinary Research and Animal Science, 58, e180290. https://doi.org/10.11606/issn.1678-4456.bjvras.2021.180290

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