Global market for veterinary herbal products during the 2018-2019 period




Herbal product, Veterinary health, Pharmaceutical industry, Marketing, Phytotherapy


The industrial manufacturing of natural products for veterinary use represents a major weakness in the veterinary sector despite increased interest and the traditional ancestral knowledge that supports them. A cross-sectional, descriptive observational study was conducted to characterize the veterinary herbal products marketed worldwide during 2018 and 2019. A comprehensive thematic search limited to the 2018-2019 period was performed in the ScienceDirect, Scopus, PubMed, Web of Science, ResearchGate, and Academic Search Complete databases. The investigation identified 487 products registered in the global market manufactured by 54 companies, led by India, The Netherlands, and the United Kingdom. The market segments of animal production and phytomedicines were dominant with 73.7% and 53.0% of products, respectively. Cattle (22.2%), sheep-goats (16.2%), and canines (16.2%) were the most favored species. The most represented therapeutic indications were those intended to treat gastrointestinal disorders (30.47%), antimicrobials (16.66%), and antiparasitic agents (10.47%). The families Fabaceae, Lamiaceae, Asteraceae, Apiaceae, Malvaceae, and Rutaceae stood out because of their frequent use, encompassing 35.0% of the 137 declared species. Andrographis paniculata (Burm.f.) Nees and Withania somnifera (Lin) Dunal were the most important species. Oral formulations for internal use (72%) and liquids (51%) in 100 mL, 500 mL, and 1 L presentations showed the highest prevalence on the market. The global market for veterinary herbal products during the 2018-2019 period was relevant in the productive and medical animal sector. No differences were found between medicinal plant species used to formulate herbal products for human and animal use.


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Abdelhafez OH, Othman EM, Fahim JR, Desoukey SY, Pimentel-Elardo SM, Nodwell JR, Schirmeister T, Tawfike A, Abdelmohsen UR. Metabolomics analysis and biological investigation of three Malvaceae plants. Phytochem Anal. 2020;31(2):204-14. PMid:31390115.

Abdul AM, Hasan KA, Pieroni A. Ethnoveterinary plants of Pakistan: a review. J Ethnobiol Ethnomed. 2020;25(16):1-18. PMid:32414421.

Astorga F, Navarrete-Talloni MJ, Miró MP, Bravo V, Toro M, Blondel CJ, Hervé-Claude LP. Antimicrobial resistance in E. coli isolated from dairy calves and bedding material. Heliyon. 2019;5(11):e02773. PMid:31844709.

Ayrle H, Mevissen M, Kaske M, Nathues H, Gruetzner N, Melzig M, Walkenhorst M. Medicinal plants-prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review. BMC Vet Res. 2016;12(1):89. PMid:27268043.

Aziz MA, Adnan M, Khan AH, Sufyan M, Khan SN. Cross cultural analysis of medicinal plants commonly used in ethnoveterinary practices at south waziristan agency and bajaur agency, Federally Administrated Tribal Areas (FATA), Pakistan. J Ethnopharmacol. 2018a;210:443-68. PMid:28917974.

Aziz MA, Khan AH, Adnan M, Ullah H. Traditional uses of medicinal plants used by indigenous communities for veterinary practices at Bajaur Agency, Pakistan. J Ethnobiol Ethnomed. 2018b;14(1):11. PMid:29378636.

Bhadane BS, Patil MP, Maheshwari VL, Patil RH. Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review. Phytother Res. 2018;32(7):1181-210. PMid:29575195.

Bibbo J, Rodriguez K, O’Haire M. Impact of service dogs on family members’ psychosocial functioning. Am J Occup Ther. 2019;73(3):7303205120. PMid:31120842.

Bijak M. Silybin, a major bioactive component of Milk Thistle (Silybum marianum L. Gaernt.)-chemistry, bioavailability, and metabolism. Molecules. 2017;22(11):1942.

Calixto JB. The role of natural products in modern drug discovery. An Acad Bras Cienc. 2019;91(Suppl 3):e20190105. PMid:31166478.

Calzetta L, Pistocchini E, Leo A, Roncada P, Ritondo BL, Palma E, di Cave D, Britti D. Anthelminthic medical plants in veterinary ethnopharmacology: anetwork meta analysis following the PRISMA-P and PROSPERO recommendations. Heliyon. 2020;6(2):e03256. PMid:32055724.

Charlier L, Rinaldi V, Musella HW, Ploeger E, Chartier C, Vineer HR, Hinney B, von Samson-Himmelstjerna G, Băcescu B, Mickiewicz M, Mateus TL, Martinez-Valladares M, Quealy S, Azaizeh H, Sekovska B, Akkari H, Petkevicius S, Hektoen L, Höglund J, Morgan ER, Bartley DJ, Claerebout E. Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe. Prev Vet Med. 2020;182:105103. PMid:32750638.

Coimbra AT, Ferreira S, Duarte AP. Genus ruta: A natural source of high value products with biological and pharmacological properties. J Ethnopharmacol. 2020;260:113076. PMid:32534112.

Collignon PJ, McEwen SA. One Health-its Importance in helping to better control antimicrobial resistance. Trop Med Infect Dis. 2019;4(1):22. PMid:30700019.

Cruz UF. Tendencias para la producción bovina mundial. Rev Cienc Anim. 2011;1(4):97-103.

Dai Y., Chen S.R., Chai L., Zhao J., Wang Y. & Wang Y. 2019. Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide. Crit Rev Food Sci Nutr. 59(suppl 1): S17-S29.

Dewangan A, Sahu BP, Meher B. Review on pharmacological potential of Ocimum sanctum L. Adv J Bio Mol. 2020;1(1):17-24. Domínguez OA, Polanco R, Cossío G, Morejón Y, Riquenes Y. Current trends and perspectives in veterinary vaccine production. Biotecnol Apl. 2014;31:196-203.

Dutta R, Khalil R, Green R, Mohapatra SS, Mohapatra S. Withania somnifera (Ashwagandha) and Withaferin A: potential in integrative oncology. Int J Mol Sci. 2019;20(21):5310. PMid:31731424.

Elango G, Rahuman AA. Evaluation of medicinal plant extracts against ticks and fluke. Parasitol Res. 2011;108(3):513-9. PMid:20922419.

Feiyang M, Shixin X, Zhaoxin T, Zekun L, Lu Z. Use of antimicrobials in food animals and impact of transmission of antimicrobial resistance on humans. Biosaf Heal. 2019;3(1):32- 8.

Feyera T, Mekonnen E, Wakayo BU, Assefa S. Botanical ethnoveterinary therapies used by agro-pastoralists of Fafan zone, Eastern Ethiopia. BMC Vet Res. 2017;13(1):232. PMid:28793900.

Figueroa AA, Pineda RS, Godínez JF, Vargas AD, Rodríguez BE, 2018. Parásitos gastrointestinales del ganado bovino y caprino en Quechultenango, Guerrero, Mexico. Agro Product. 11(6):97-104.

Fourati M, Smaoui S, Hlima HB, Elhadef K, Braïek OB, Ennouri K, Mtibaa AC, Mellouli L, Ennouri K, Mellouli L. Bioactive compounds and pharmacological potential of Pomegranate (Punica granatum) seeds. A Review. Plant Foods Hum Nutr. 2020;75(4):477-86. PMid:33040298.

Friedrich T. Producción de alimentos de origen animal. Actualidad y perspectivas. Rev Cub Cienc Agric. 2014;1(48):5-6.

Gucwa K, Milewski S, Dymerski T, Szweda P. Investigation of the antifungal activity and mode of action of Thymus vulgaris, Citrus limonum, Pelargonium graveolens, Cinnamomum cassia, Ocimum basilicum, and Eugenia caryophyllus essential oils. Molecules. 2018;23(5):1116. PMid:29738503.

Hernández J, Zaragoza A, López G, Peláez A, Olmedo A, Rivero N. Actividad antibacteriana y sobre nematodos gastrointestinales de metabolitos secundarios vegetales: enfoque en medicina veterinaria. Abanico Vet. 2018;8(1):14- 27.

Hossain M, Mizanur Rahman SM. Structure characterization and quantification of a new isoflavone from the arial parts of Phyllanthus niruri. Arab J Chem. 2019;12(8):2257-61.

Iannino F, Salucci S, Di Donato G, Badagliacca P, Vincifori G, Di Giannatale E. Campylobacter and antimicrobial resistance in dogs and humans: “One health” in practice. Vet Ital. 2019;55(3):203-20. PMid:31599545.

Javir G, Joshi K. Evaluation of the combinatorial effect of Tinospora cordifolia and Zingiber officinale on human breast cancer cells. 3 Biotech. 2019;9(11):428.

Lans C. Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care? J Ethnopharmacol. 2019;236:366-92. PMid:30772483.

Lass-Hennemann J, Schäfer SK, Sopp MR, Michael T. The relationship between dog ownership, psychopathological symptoms and health-benefitting factors in occupations at risk for traumatization. Int J Environ Res Public Health. 2020;17(7):2562. PMid:32276495.

Lu XF, Lin PC, Zi JC, Fan XN. Limonoids from seeds of Azadirachta indica and their antibacterial activity. Zhongguo Zhong Yao Za Zhi. 2019;44(22):4864-73. PMid:31872594.

Ma S, Wang X, Lai F, Lou C. The beneficial pharmacological effects and potential mechanisms of picroside II: evidence of its benefits from in vitro and in vivo. Biomed Pharmacother. 2020;130:110421. PMid:32674016.

Martínez G, Jiménez N. Plantas de interés veterinario en la cultura campesina de la Sierra de Ancasti (Catamarca, Argentina). Bol Latinoam Caribe Plantas Med Aromat. 2017;(16):4, 329-46.

McEwen S, Collignon P. Antimicrobial Resistance: a One Health Perspective. Microbiol Spectr. 2018;6(2):1-26. PMid:29600770.

McGaw LJ, Famuyide IM, Khunoana ET, Aremu AO. Ethnoveterinary botanical medicine in South Africa: A review of research from the last decade (2009 to 2019). J Ethnopharmacol. 2020;257:112864. PMid:32302713.

McVey S, Shi J. Vaccines in veterinary medicine: a brief review of history and technology. Vet Clin Small Anim. 2010;40(3):381-92.

Mengual-Moreno E, Lizarzábal-García M, Hernández Rincón I, Barboza-Nobrega MF. Hepatotoxicidad asociada a hierbas y productos nutricionales de origen botánico. Invest Clin. 2015;56(3):320-35.

Mertenat D, Cero MD, Vogl CR, Ivemeyer S, Meier B, Maeschli A, Hamburger M, Walkenhorst M. Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland– is there potential to extend veterinary options to reduce antimicrobial use? J Ethnopharmacol. 2020;246:112184. PMid:31465817.

Miara MD, Bendif H, Ouabed A, Rebbas K, Ait Hammou M, Amirat M, Greene A, Teixidor-Toneu I. Ethnoveterinary remedies used in the Algerian steppe: exploring the relationship with traditional human herbal medicine. J Ethnopharmacol. 2019;244:112164. PMid:31419498.

Murugan K, Kalaivani P, Vanitha V, Bothiraj KV. Phytopharmacological and antioxidant analysis of hydroethanolic extract of Boerhavia diffusa. Int J Res Pharm Sci. 2020;11(1):840-6.

Mutua F, Sharma G, Grace D, Bandyopadhyay S, Shome B, Lindahl J. A review of animal health and drug use practices in India, and their possible link to antimicrobial resistance. Antimicrob Resist Infect Control. 2020;9(1):2-13. PMid:32641109.

Nigam M, Mishra AP, Adhikari-Devkota A, Dirar AI, Hassan MM, Adhikari A, Belwal T, Devkota HP. Fruits of Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities. Phytother Res. 2020;34(10):2518-33. PMid:32307775.

Nisar MF, He J, Ahmed A, Yang Y, Li M, Wan C. Chemical components and biological activities of the Genus Phyllanthus: A Review of the Recent Literature. Molecules. 2018;23(10):2567. PMid:30297661.

Peng M, Zhao X, Biswas D. Polyphenols and tri-terpenoids from Olea europaea L. in alleviation of enteric pathogen infections through limiting bacterial virulence and attenuating inflammation. J Funct Foods. 2017;36:132-43.

Pietruszewska W, Barańska M, Wielgat J. Place of phytotherapy in the treatment of acute infections of upper respiratory tract and upper gastrointestinal tract. Otolaryngol Pol. 2018;72(4):42-50. PMid:30220668.

Rose P, Moore PK, Whiteman M, Zhu YZ. An appraisal of developments in Allium sulfur chemistry: expanding the pharmacopeia of garlic. Molecules. 2019;24(21):4006. PMid:31694287.

Sabir MN, Saour KY, Rachid S. In vitro cytotoxic and antimicrobial effects of a novel peroxysesquiterpene glucoside from the rhizomes of Cyperus rotundus L (Cyperaceae). Trop J Pharm Res. 2020;19(2):331-9.

Saggam A, Tillu G, Dixit S, Chavan-Gautam P, Borse S, Joshi K, Patwardhan B. Withania somnifera (L.) Dunal: a potential therapeutic adjuvant in cancer. J Ethnopharmacol. 2020;255:112759. PMid:32173425.

Saha PS, Sarkar S, Jeyasri R, Muthuramalingam P, Ramesh M, Jha S. In Vitro propagation, phytochemical and neuropharmacological profiles of Bacopa monnieri (L.) Wettst.: A Review. Plants (Basel). 2020;9(4):411. PMid:32224997.

Santhan P. A field study on Indian medicinal plants. J Med Plants Res. 2020;8(4):198-205. Sen T, Samanta SK. Medicinal plants, human health and biodiversity: a broad review. Adv Biochem Eng Biotechnol. 2015;147:59-110. PMid:25001990.

Sharifi-Rad J, Melgar-Lalanne G, Hernández-Álvarez AJ, Taheri Y, Shaheen S, Kregiel D, Antolak H, Pawlikowska E, Brdar-Jokanović M, Rajkovic J, Hosseinabadi T, Ljevnaić Mašić B, Baghalpour N, Mohajeri M, Fokou PVT, Martins N. Malva species: insights on its chemical composition towards pharmacological applications. Phytother Res. 2020;34(3):546-67. PMid:31713320.

Sharma R, Manhas RK. Ethnoveterinary plants for the treatment of camels in Shiwalik regions of Kathua district of Jammu & Kashmir, India. J Ethnopharmacol. 2015;169:170-5. PMid:25917839.

Singh R, Geetanjali. Asparagus racemosus: a review on its phytochemical and therapeutic potential. Nat Prod Res. 2016;30(17):1896-908. PMid:26463825.

Singh SN, Moses A, David A. Antimicrobial activity of Emblica officinalis extracts against selected bacterial pathogens. Int J Basic Appl Res. 2019;9(1):325-30.

Sornpet B, Potha T, Tragoolpua Y, Pringproa K. Antiviral activity of five Asian medicinal pant crude extracts against highly pathogenic H5N1 avian influenza virus. Asian Pac J Trop Med. 2017;10(9):871-6. PMid:29080615.

Stucki K, Cero MD, Vogl CR, Ivemeyer S, Meier B, Maeschli A, Hamburger M, Walkenhorst M. Ethnoveterinary contemporary knowledge of farmers in pre-alpine and alpine regions of the Swiss cantons of Bern and Lucerne compared to ancient and recent literature-is there a tradition? J Ethnopharmacol. 2019;234:225-44. PMid:30572090.

Suroowan S, Javeed F, Ahmad M, Zafar M, Noor MJ, Kayani S, Javed A, Mahomoodally MF. Ethnoveterinary health management practices using medicinal plants in South Asia-a review. Vet Res Commun. 2017;41(2):147-68. PMid:28405866.

Swartz TH, Schramm HH, Petersson-Wolfe CS. Association between neonatal calf diarrhea and lying behaviors. Vet Anim Sci. 2020;9:100111. PMid:32734112.

Tilahun M, Etifu M, Shewage T. Plant diversity and ethnoveterinary practices of Ethiopia: a systematic review. Evid Based Complement Alternat Med. 2019;5276824:5276824. PMid:30723514.

Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: a review. I. Pharm Sci. 2011;1(1):98-106.

Van Boeckel T.P., Pires J., Silvester R., Zhao C., Song J., Criscuolo N.G., Gilbert M., Bonhoeffer S. & Laxminarayan R., 2019. Global trends in antimicrobial resistance in animals in low and middle-income countries. Science. 365(6459):eaaw1944.

Wanzala W, Zessin KH, Kyule NM, Baumann MP, Mathias E, Hassanali A. Ethnoveterinary medicine: a critical review of its evolution, perception, understanding and the way forward. Livest Res Rural Dev. 2005;17(11):1-41.

Yadav V, Krishnan A, Vohora D. A systematic review on Piper longum L.: bridging traditional knowledge and pharmacological evidence for future translational research. J Ethnopharmacol. 2020;247:112255. PMid:31568819.

Yigezu Y, Haile DB, Ayen WY. Ethnoveterinary medicines in four districts of Jimma zone, Ethiopia: cross sectional survey for plant species and mode of use. BMC Vet Res. 2014;10(1):76. PMid:24679045.

Yu SJ, Yu JH, He F, Bao J, Zhang JS, Wang YY, Zhang H. New antibacterial thiophenes from Eclipta prostrata. Fitoterapia. 2020;142:104471. PMid:31917302.

Zhang L, Bao M, Liu B, Zhao H, Zhang Y, Ji X, Zhao N, Zhang C, He X, Yi J, Tan Y, Li L, Lu C. Effect of Andrographolide and its analogs on bacterial infection: a review. Pharmacology. 2020;105(3-4):123-34. PMid:31694037.




How to Cite

Rodríguez Coipel, Y. ., Domínguez Odio, A., Mena Álvarez, O. ., Toirac Proenza , R. ., González Marrero , I. ., & Cala Delgado, D. L. (2021). Global market for veterinary herbal products during the 2018-2019 period. Brazilian Journal of Veterinary Research and Animal Science, 58, e181002.