Perinatal exposure to an aromatase inhibitor glyphosate-base herbicide reduced male and female social behavior in juvenile age and the sexual behavior at adult female rat

Authors

  • Esther Lopes Ricci Universidade Presbiteriana Mackenzie, Centro de Ciências Biológicas e da Saúde, Programa de Pós-graduação em Distúrbios do Desenvolvimento ; Faculdade de Ciências da Saúde IGESP https://orcid.org/0000-0002-4222-9976
  • Miriam Oliveira Ribeiro Universidade Presbiteriana Mackenzie, Centro de Ciências Biológicas e da Saúde, Programa de Pós-graduação em Distúrbios do Desenvolvimento
  • André Rinaldi Fukushima Faculdade de Ciências da Saúde IGESP https://orcid.org/0000-0001-6026-3054
  • Thaisa Meira Sandini University of Saskatchewan, Department of Anatomy, Physiology, and Pharmacology https://orcid.org/0000-0002-7095-4243
  • Paulo Ricardo Dell’Armelina Rocha Universidade Paulista, Instituto de Ciências da Saúde, Programa de Pós-graduação em Patologia Ambiental e Experimental
  • Paula Andrea Faria Waziry Waziry Nova Southeastern University, Dr. Kiran C. Patel College of Osteopathic Medicine https://orcid.org/0000-0002-7543-8758
  • Maria Martha Bernardi Universidade Paulista, Instituto de Ciências da Saúde, Programa de Pós-graduação em Patologia Ambiental e Experimental http://orcid.org/0000-0002-6860-9416
  • Helenice de Souza Spinosa Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Programa de Pós-graduação em Patologia Experimental e Comparada https://orcid.org/0000-0003-1953-0477

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2022.186467

Keywords:

Herbicide, Sexual dimorphism, Social behavior, Perinatal treatment, Aromatase inhibitor

Abstract

Objectives: The herbicide glyphosate, a pesticide used in agriculture to control weeds, both in food crops and in other agricultural areas, has been identified as an endocrine modulator through the inhibition of aromatase activity and the activation of estrogen receptors. The present study examined the effects of a glyphosate-based herbicide (Roundup® (GLY-BH) on sexual dimorphism of rats after perinatal exposure to low and high GLY-BH in males and females offspring. Methods: Two groups of pregnant rats were treated with two doses of GLY-BH (50 or 150 mg/kg) from day 15 of gestation (GD15) to postnatal day 7 (PND7). Play fighting behavior was observed at the juvenile stage and during social and sexual behaviors in adulthood. Results: Perinatal GLY BH exposure reduced male and female body weight at 28, 75, and 90 days of age. The play fighting behavior was decreased in both sexes, but female rats were more affected. The sexual behaviors were reduced only in females. Conclusions: Perinatal exposure to both doses of GLY-BH promoted sexually dimorphic effects in both juvenile and adulthood stages. These effects were attributed to the inhibition of aromatase activity induced by exposure to GLY-BH in the perinatal period. 

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Author Biographies

  • Esther Lopes Ricci, Universidade Presbiteriana Mackenzie, Centro de Ciências Biológicas e da Saúde, Programa de Pós-graduação em Distúrbios do Desenvolvimento ; Faculdade de Ciências da Saúde IGESP

    Center of Biological Science and Health, Mackenzie Presbyterian University

  • Miriam Oliveira Ribeiro, Universidade Presbiteriana Mackenzie, Centro de Ciências Biológicas e da Saúde, Programa de Pós-graduação em Distúrbios do Desenvolvimento

     Developmental Disorders Program, Center of Biological Science and Health.

  • Thaisa Meira Sandini, University of Saskatchewan, Department of Anatomy, Physiology, and Pharmacology

    Department of Anatomy, Physiology, and Pharmacology

  • Paulo Ricardo Dell’Armelina Rocha, Universidade Paulista, Instituto de Ciências da Saúde, Programa de Pós-graduação em Patologia Ambiental e Experimental

    Graduate Program in Environmental and Experimental Pathology

  • Paula Andrea Faria Waziry Waziry, Nova Southeastern University, Dr. Kiran C. Patel College of Osteopathic Medicine

    Dr. Kiran C. Patel College of Osteopathic Medicine

  • Maria Martha Bernardi, Universidade Paulista, Instituto de Ciências da Saúde, Programa de Pós-graduação em Patologia Ambiental e Experimental

    Prof. Dra do Curso de Pós-graduação em Patologia Ambiental e Experimental da área de Medicina Veterinária da Universidade Paulista. É bióloga, com mestrado e doutorado pela Universidade de São Paulo.

  • Helenice de Souza Spinosa, Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Programa de Pós-graduação em Patologia Experimental e Comparada

    Department of Pathology, School of Veterinary Medicine and Animal Science

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1.
Ricci EL, Ribeiro MO, Fukushima AR, Sandini TM, Rocha PRD, Waziry PAFW, et al. Perinatal exposure to an aromatase inhibitor glyphosate-base herbicide reduced male and female social behavior in juvenile age and the sexual behavior at adult female rat. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2022 May 25 [cited 2024 Apr. 19];59:e186467. Available from: https://www.revistas.usp.br/bjvras/article/view/186467