Can Saccharomyces cerevisiae supplementation improve piglets’ performance and intestinal health after weaning?

Authors

  • Eduarda Buck Bernardes Guimarães Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Nutrição e Produção Animal, Laboratório de Pesquisa em Suínos https://orcid.org/0000-0002-1754-9759
  • Ana Clara Rodrigues de Oliveira Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Nutrição e Produção Animal, Laboratório de Pesquisa em Suínos https://orcid.org/0000-0003-3908-6107
  • Bruno Braga Carnino Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Nutrição e Produção Animal, Laboratório de Pesquisa em Suínos https://orcid.org/0000-0001-8697-6247
  • Laya Kannan Silva Alves Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Nutrição e Produção Animal, Laboratório de Pesquisa em Suínos ; North Carolina State University, College of Veterinary Medicine, Department of Population Health and Pathobiology https://orcid.org/0000-0002-9534-6121
  • Ricardo Luiz Moro de Sousa Universidade de São Paulo, Faculdade de Zootecnia e Engenharia de Alimentos, Departamento de Medicina Veterinária, Laboratório de Higiene Zootécnica https://orcid.org/0000-0001-7327-3999
  • Monique Danielle Pairis-Garcia North Carolina State University, College of Veterinary Medicine, Department of Population Health and Pathobiology https://orcid.org/0000-0002-6005-5666
  • Cesar Augusto Pospissil Garbossa Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Nutrição e Produção Animal, Laboratório de Pesquisa em Suínos https://orcid.org/0000-0003-3244-7184

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2024.215917

Keywords:

Escherichia coli, Gut microbiota, Nursery phase, Probiotics, Swine

Abstract

This study aimed to assess the impact of two commercial Saccharomyces cerevisiae strains (CHY1 and CHY2) on the intestinal health and performance of weaned piglets challenged with enterotoxigenic Escherichia coli during the nursery phase. One hundred ninety-two piglets with an average weight of 6.70 ± 0.92 kilograms were allocated in a randomized block design to one of four treatments: a negative control (C) without E. coli challenge and no yeast supplementation; a positive control (CH) with E. coli challenge and no yeast supplementation; and two treatment groups receiving an E. coli challenge with a CHY1 and CHY2 yeast strain supplementation. The challenge involved inoculating piglets with two dosages of E. coli F4 (106 CFU/ml and 109 CFU/ml) and a saline solution for the C group. Samples of intestinal tissue, blood, and cecal content were collected on the trial’s 11th, 28th, and 42nd days. All variables were subjected to analysis of variance, and upon detecting significant differences via the F-test (p < 0.05), Tukey’s test was applied to compare treatment means. For the analysis of diarrhea occurrence, the Kruskal-Wallis test was applied. When variables were rejected at a 5% probability level, a Dunn’s test was conducted as a post-hoc analysis for paired multiple comparisons (p < 0.05), with statistical significance set at this level. Weaned piglets supplemented with CHY1 exhibited superior performance metrics, including higher average daily gain (15.3% increase), body weight (3.4% increase), feed-to-gain ratio (9.5% increase), and average daily feed intake (12.3% increase) at 28 days compared to the CH group across two different nutritional phases. No discernible effects were observed on measuring blood parameters, intestinal morphology, or cecal short-chain fatty acids. Both yeast-treated groups displayed improved performance during the most challenging periods. However, the CHY1 yeast strain contributed to enhanced piglet performance in the initial 28 days without inducing changes in intestinal morphology. 

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Published

2024-05-02

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1.
Guimarães EBB, Oliveira ACR de, Carnino BB, Alves LKS, Sousa RLM de, Pairis-Garcia MD, et al. Can Saccharomyces cerevisiae supplementation improve piglets’ performance and intestinal health after weaning?. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2024 May 2 [cited 2024 Jun. 15];61:e215917. Available from: https://www.revistas.usp.br/bjvras/article/view/215917