Influence of Enzootic Bovine Leukosis on phagocytic function of circulating leukocytes from animals with persistent lymphocytosis
Keywords:Bovine, Leukocytes, Phagocytosis, Enzootic Bovine Leukosis, Flow Cytometry
AbstractThis study evaluated the phagocytosis of propidium iodide-labeled Staphylococcus aureus (PI-Sa) by circulating leukocytes obtained from five Enzootic Bovine Leukosis (EBL)-negative cows, five naturally EBL-infected, non-lymphocytotic cows, and five EBL-positive cows with persistent lymphocytosis (PL), analyzed by flow cytometry. Among cells obtained from EBL-infected cows, presenting PL, the percentage of leukocytes carrying out phagocytosis (7.20%), was smaller (p=0.047) than that verified among cells obtained from non-infected (12.90%), and from BLV-infected, non-lymphocytotic cows (14.70%). Furthermore, leukocytes obtained from EBL-infected cows, presenting PL, showed smaller phagocytosis intensity (characterized by the intensity of propidium iodide fluorescence) than leukocytes obtained from non-infected and from EBL-infected, non-lymphocytotic, cows (p<0.001). Therefore, results show a decreased phagocytic function among circulating leukocytes obtained from BLV-infected, lymphocytotic cows.
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Azedo, M. R., Massoco, C. de O., Blagitz, M. G., Sanches, B. G. S., Souza, F. N. de, Batista, C. F., Sakai, M., Sá-Rocha, L. C. de, Kfoury Junior, J. R., Stricagnolo, C. R., Benesi, F. J., & Libera, A. M. M. P. D. (2008). Influence of Enzootic Bovine Leukosis on phagocytic function of circulating leukocytes from animals with persistent lymphocytosis. Brazilian Journal of Veterinary Research and Animal Science, 45(5), 390-397. https://doi.org/10.11606/issn.1678-4456.bjvras.2008.26681
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