Ammonia poisoning in cattle fed extruded or prilled urea: alterations in some chemistry components
Keywords:Urea, Ammonia, Bovines, Poisoning, Biochemical changes
AbstractTwelve yearling Girolando steers never fed urea before were assigned randomly in two groups of six animals each. In both groups were administered intraruminally a single dose (0.5 g/kg BW) of extruded or prilled urea in order to induce ammonia poisoning. Plasma or serum levels of ammonia, urea, creatinine, glucose, L-lactate were determined. Hematocrit values were also recorded. Blood samples were taken before the administration of urea, at the onset of muscle tremors, at the first convulsive episode, and 240 minutes after the beginning of the urea feeding. Hyperammonemia already occured at the time of the first muscle tremors. Glucose and L-lactate levels were higher at the peak of the intoxication (convulsive episode), which were higher compared to the beginning of the experiment. Endogenous production of urea increased during the experiment due to hyperammonemia (r = 0.57), reaching peak levels at the end of the trials. Higher ammonia values lead to increased concentrations of L-lactate, glucose, urea, creatinine and hematocrit values. These results showed that high levels of ammonia increased glyconeogenesis, anaerobic glycolysis, the endogenous synthesis of urea and the level of dehydration. L-lactate and glucose were the best variables to monitor biochemical changes in cases of ammonia poisoning.
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How to Cite
Antonelli, A. C., Torres, G. A. S., Mori, C. S., Soares, P. C., Maruta, C. A., & Ortolani, E. L. (2009). Ammonia poisoning in cattle fed extruded or prilled urea: alterations in some chemistry components. Brazilian Journal of Veterinary Research and Animal Science, 46(1), 69-76. https://doi.org/10.11606/issn.1678-4456.bjvras.2009.26752
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