Ceruloplasmin concentration in dogs with multicentric lymphoma undergoing chemotherapy

Authors

  • Sílvia Regina Ricci Lucas Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Alexandre Merlo Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Regina Mieko Sakata Mirandola Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Thais Paione Gasparin Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26810

Keywords:

Ceruloplasmin, Lymphoma, Dogs, Acute phase protein

Abstract

Ceruloplasmin (Cp) is a positive acute phase protein, responsible for the transport of copper and protection of cells and tissue against oxidant compounds. The aim of this study was to evaluate Cp concentrations at diagnosis and during chemotherapy in dogs with multicentric lymphoma (ML). Cp was measured using orto dianisine technique, in two groups of dogs: ten healthy dogs (control) and 13 dogs with ML. All dogs were submitted to chemotherapy. Dogs with signs of concurrent disease or that have been previously treated with prednisone were excluded from the study. Cp measurement was done before treatment and once a week, during the first month of chemotherapy, and each 3-week intervals until the relapse for dogs with ML, and until the 16th week in control dogs. ANOVA test followed by multiple Tukey's tests were used to compare the groups. There was no difference between the mean of Cp concentration in dogs with ML at the diagnosis when compared to healthy dogs (p >; .05). Levels of Cp decreased significantly at 4th week when compared to the first week, but Cp increase was not observed at the relapse. At all other times during the treatment, Cp concentrations for dogs with lymphoma were not significantly different from controls submitted to chemotherapy. As conclusion, Cp levels in ML at diagnosis were similar to healthy dogs, decreased when lymphoma remission was achieved and there was no change at the relapse.

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Published

2010-12-01

Issue

Section

UNDEFINIED

How to Cite

1.
Lucas SRR, Merlo A, Mirandola RMS, Gasparin TP. Ceruloplasmin concentration in dogs with multicentric lymphoma undergoing chemotherapy. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2010 Dec. 1 [cited 2024 Nov. 12];47(6):477-82. Available from: https://www.revistas.usp.br/bjvras/article/view/26810