Phenylbutazone effects on experimental wound healing in horses

Authors

  • Carlos Alberto Hussni Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP
  • Tanja Melanie Groh Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP
  • Ana Liz Garcia Alves Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP
  • Adalberto José Crocci Universidade Estadual Paulista, Instituto de Biociências, Departamento de Bioestatística, Botucatu, SP
  • José Luiz de Mello Nicoletti Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP
  • Marcos Jun Watanabe Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia e Anestesiologia Veterinária, Botucatu, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26824

Keywords:

Healing, Wound, Phenylbutazone, Horses

Abstract

The purpose of this study was to investigate phenylbutazone effects on second intention wound healing, and to compare the healing process between the thoracic and lumbar areas. Ten horses were submitted to circular full-thickness wound produced on both sides of the thoracic and lumbar areas. Animals were gathered into two experimental groups, one receiving daily IV injections of phenylbutazone (4,4mg/kg) and the other (control group) distillated water for five days. All wounds were daily treated with local Dakin's solution. The wound contraction rates were determined by serial measurements each 72 hours. At the 6th and 15th post surgical days, biopsies were performed for histological analysis. Thoracic and lumbar wound contraction was decreased in the phenylbutazone group. The time to complete healing was significantly greater in phenylbutazone group (49 days) than in control group (37 days). There was no significant difference between thoracic and lumbar area in the same group. Gross and histopathology analysis showed the inhibitory effect of phenylbutazone on the second-intention wound healing when compared to the control group.

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Published

2010-08-01

Issue

Vol. 47 No. 4 (2010)

Section

UNDEFINIED

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Hussni CA, Groh TM, Alves ALG, Crocci AJ, Nicoletti JL de M, Watanabe MJ. Phenylbutazone effects on experimental wound healing in horses. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2010 Aug. 1 [cited 2024 Dec. 2];47(4):262-7. Available from: https://www.revistas.usp.br/bjvras/article/view/26824