Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats

Authors

  • Cristiane Moraes Barbosa Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Michiko Sakate Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Annelise Carla Camplesi Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Maria do Carmo Fernandez Vailati Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Lívia Fagundes Moraes Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Regina Kiomi Takahira Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26835

Keywords:

Sodium diclofenac, Meloxicam, Firocoxib, Laboratories parameters, Rats

Abstract

This work has evaluated the hematological and biochemical profile by the use of sodium diclofenac, meloxicam and firocoxib in Wistar rats. The rats were distributed in groups: G1 (control), G2 (diclofenac sodium: 15 mg/kg), G3 (meloxicam: 2.0 mg/ kg), G4 (meloxicam: 10.0 mg/ kg), G5 (firocoxib: 5.0 mg/ kg) e G6 (firocoxib: 25.0 mg/ kg). The drugs were administered intragastrically (gavage) once a day, during five days and evaluated in three moments: M1 (48 hours after the beginning of the treatment), M2 (96 hours after the beginning of the treatment) and M3 (72 hours after the ending of the treatment). In each moment of each group, five to seven animals were evaluated and laboratory exams were performed. There were no significant changes observed in the biochemical and hematological parameters by the use of meloxicam and firocoxib. One of the effects of the sodium diclofenac was eritrogram variation as hematocrit, erythrocytes, hemoglobin decrease during the treatment. In addition, the platelets and total white blood cells counts did not change except for basophil. There was no changes in AST, ALP, GGT, urea, creatinine, sodium, potassium values. However, the values of protein, globulin and albumin decreased. It was concluded that diclofenac sodium does not provide large variations in the hemogram and biochemical profile than the meloxicam and firocoxib do not provide delletery effects in laboratories tests.

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Published

2010-04-01

How to Cite

Barbosa, C. M., Sakate, M., Camplesi, A. C., Vailati, M. do C. F., Moraes, L. F., & Takahira, R. K. (2010). Evaluations hematological and biochemical by the use of sodium diclofenac, meloxicam and firocoxib in rats. Brazilian Journal of Veterinary Research and Animal Science, 47(2), 117-124. https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26835

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