Evaluation of different proportions of calcium phosphate in the regeneration of bone tissue of rabbits: clinical-surgical, radiological and histological study

Authors

  • Adilío Santos de Azevedo Universidade Federal de Campina Grande, Centro de Saúde e Tecnologia Rural, Unidade Acadêmica de Medicina Veterinária, Patos, PB
  • Marcelo Jorge Cavalcanti de Sá Universidade Federal de Campina Grande, Centro de Saúde e Tecnologia Rural, Unidade Acadêmica de Medicina Veterinária, Patos, PB
  • Pedro Isidro da Costa Neto Universidade Federal de Campina Grande, Centro de Saúde e Tecnologia Rural, Unidade Acadêmica de Medicina Veterinária, Patos, PB
  • Marcus Vinícius Lia Fook Universidade Federal de Campina Grande, Unidade Acadêmica de Engenharia de Materiais, Campina Grande, PB
  • Roseane de Araújo Portela Universidade Federal de Campina Grande, Centro de Saúde e Tecnologia Rural, Unidade Acadêmica de Medicina Veterinária, Patos, PB
  • Sérgio Santos de Azevedo Universidade Federal de Campina Grande, Centro de Saúde e Tecnologia Rural, Unidade Acadêmica de Medicina Veterinária, Patos, PB

DOI:

https://doi.org/10.11606/issn.2318-3659.v49i1p12-18

Keywords:

Biomaterials, Bone healing, Surgery

Abstract

The aim of this study was to evaluate the calcium phosphate, calcium pyrophosphate (CPP) with heat treatment at 700 and 900 ° C, tricalcium phosphate combined with hydroxyapatite (TCP/HA) and hydroxyapatite (HA) as bone substitutes. We used 20 rabbits (Oryctolagus cuniculus) of both sexes, New Zealand breed, with mean weigh of 2.5 ± 0.41 kg. The animals were randomly divided into two groups of 10 animals in the period in which they were euthanized (30 or 60 days). The implants were placed on the proximal and distal metaphysis of each femur so that CPP 700 and 900 were introduced in the left, while TCP/HA and HA in the right. Clinical and radiographic-surgical evaluations were performed immediately after surgery, and 30 and 60 days post-surgery. The animals showed normal clinical evolution. In the radiographic evaluation there was statistical difference between groups with higher degree of radiopacity at group 60 days that used TCP/HA and HA implants. In the histological evaluation by light microscopy and morphometric analysis the materials TCP/HA and HA showed greater one formation around the implants than CPP700 and CPP900 at 30 and 60-days evaluation.

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Published

2012-02-03

Issue

Section

UNDEFINIED

How to Cite

Evaluation of different proportions of calcium phosphate in the regeneration of bone tissue of rabbits: clinical-surgical, radiological and histological study. (2012). Brazilian Journal of Veterinary Research and Animal Science, 49(1), 12-18. https://doi.org/10.11606/issn.2318-3659.v49i1p12-18