Effect of the ethanolic extract from green propolis on production of antibodies after immunization against canine parvovirus (CPV) and canine coronavirus (CCoV)
Keywords:Propolis, Th1/Th2, Immunomodulation, Vaccine, Canine parvovirus, Canine coronavirus
AbstractThis study was designed to evaluate whether an ethanolic extract of green propolis (EEP) can interfere with production of specific antibodies after immunization against parvovirus (CPV) and canine coronavirus (CCoV). Mice were vaccinated with CPV and CCoV (0.75, 1.5 and 3 x 106 TCID50) with or without 400 μg/dose of the EEP. Twenty one days after the third dose was measured serum IgG. The co-administration of the EEP significantly enhanced serum specific IgG responses to CPV in animals inoculated with the highest concentration of the antigen, and had no influence on levels of antibodies to CCoV. The results indicate that the EEP has immunomodulatory action closely dependent on the type and concentration of antigen used, being able to increase the levels of antibodies to CPV.
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Ferreira, L. das N., Finger, P. F., Castro, C. C. de, Siedler, B. S., Munhoz, L. S., Vargas, G. D., Fischer, G., & Hübner, S. de O. (2012). Effect of the ethanolic extract from green propolis on production of antibodies after immunization against canine parvovirus (CPV) and canine coronavirus (CCoV). Brazilian Journal of Veterinary Research and Animal Science, 49(2), 116-121. https://doi.org/10.11606/issn.2318-3659.v49i2p116-121
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