The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone

Authors

  • Julieta Rodini Engrácia de Moraes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP
  • Flávio Ruas de Moraes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP
  • Gervásio Henrique Bechara Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP

DOI:

https://doi.org/10.11606/issn.2318-3659.v33i1p11-14

Keywords:

Chloramphenicol, Pleurisy, Carrageenin, Dextran, Indomethacin, Dexamethasone.

Abstract

The effect of indomethacin and dexamethasone on PMN cell migration was studied in relation to chloramphenicol in the pleural cavity of rats, 4 hours after local injection of carrageenin or dextran. Pre-treatment of rats with chloramphenicol succinate (30mg/kg), ip, every 12h, during 4 days, potentiated the migration of PMN leucocytes to the inflamed cavity, when carrageenin (150mcg) was used as an irritant. However, responses to dextran (100mcg) remained the same. Chloramphenicol pre-treated rats that received
indomethacin (2mg/kg, per os, 30min before carrageenin) or dexamethasone (0.25mg/kg, ip, 30min before carrageenin) showed inhibition of potentiated cellular responses. Mechanisms of the potentiating effect of chloramphenicol on the acute carrageenin-induced inflammation remains unclear.

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Published

1996-03-01

How to Cite

Moraes, J. R. E. de, Moraes, F. R. de, & Bechara, G. H. (1996). The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone. Brazilian Journal of Veterinary Research and Animal Science, 33(1), 11-14. https://doi.org/10.11606/issn.2318-3659.v33i1p11-14

Issue

Section

BASIC SCIENCES

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