Cellular exudation induced by carrageenan in the peritoneal cavity of chicks

Abstract

The cellular response, induced by the carrageenan injection (4.5 ml; 0.2% w/v) in Ringer-Locke solution into the peritoneal cavity of chicks (three to six-week old Isa Brown males), was evaluated by total and differential inflammatory cell counting of exudates collected 0.5 to 4 hours after stimulus. An increased leucocyte exudation, with predominance of heterophils, was
observed within 1 and 4 hours post-stimulus. Macrophages were the second predominant cell type, followed by lymphocytes, eosinophils and basophils, in decreasing order. Thrombocytes were not significant in the peritoneal inflammatory exudate. Results presented in this work indicate that the peritoneal cavity can be utilized as a good model for studying the acute
inflammatory response of chickens.