Influence of BCG inespecific stimulation on the hamsters susceptibility to the experimentai infection L. interrogans serovar pomona
Keywords:Leptospirosis, Leptospira interrogans, BCG
The influence of BCG on the resistance of hamsters experimentally infected with Leptospira interrogans serovar pomona was investigated. Forty-eight young male hamsters were used as the follow: 23 of them have administered two intraperitoneal dosis of BCG with seven days of interval: the remaining 25 were treated with placebo (Souton solution) in the same way as in the BCG treatment. On the third day after the second BCG or placebo administration, each animal was inoculated with 0.5 ml of a suspension of L. pomona through the intraperitoneal route. The animals were observed for signs and symptoms of leptospirosis during a period of 21 days and those in the agonic state of disease were killed and their kidney and serum samples were taken for the demonstration of antibodies and leptospiroses, by means of serum agglutination test and by the direct culture of kidney fragments. All of the survivors were killed at the 21st day post infection and evaluated for antibodies an leptospires, as described above. For the BCG treated group, no death was recorded (0/23 or 0,00%) whereas in the control group 80% of deaths (20/25) were observed.
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