Kinetic of vascular and cellular alterations in the carrageenin-induced peritonitis in Gallus gallus. Effect of steroidal and non-steroidal antiinflamatory drugs

Authors

  • Cristina Miyuki Hara Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Manuel Henrique Klein Júnior Universidade Federal do Piauí, Teresina, PI.
  • Julieta Rodini Engrácia de Moraes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Flávio Ruas de Moraes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Antonio Carlos Paulillo Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.1994.52061

Keywords:

Carrageenin, Inflammation, Peritonitis, Indometacin, Piroxican, Dexamethasone, Gallus gallus

Abstract

The kinetic of vascular and cellular alterations in the carrageenin-induced peritonitis was investigated (500 mcg) in Gallus gallus and the effect of the pre-treatment with dexamethasone (0.5; 1.0 or 2.0 mg/kg), indomethacin (2.0; 4.0 or 8.0 mg/kg), pyroxiean (20.0; 40.0 or 80.0 mg/kg), given by oral route 30 minutes before the inflammatory stimulus. It was observed that the highest increase in both vascular permeability and leucocyte accumulation ocurred respectively 150 minutes and 4 hours after the carrageenin injection. Polymorphonuclear leukocytes were the predominant cell type in the exudate obtained 2 and 4 hours after the stimulus. An equilibriun between polymorphonuclear and mononuclear cells was observed with 24 hours of inflammation and the latter cell type was predominant after 48 hours. The pre-treatment with indomethacin and pyroxiean significantly (p<0.05) inhibited the vascular permeability increase but not the leukocytes counts. Dexamethasone was significantly reduced both vascular permeability increase and leukocyte accumulation. These results suggest that eicosanoids have a role in the vascular permeability increase but it is less relevant in the leuchocyte chemotaxis in carrageenin-induced acute inflammation in fowls. The vascular permeability increase and cellular migration are independent phenomena when the effect of antiinflammatory drugs are concerned.

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Published

1994-12-03

Issue

Section

BASIC SCIENCES

How to Cite

1.
Hara CM, Klein Júnior MH, Moraes JRE de, Moraes FR de, Paulillo AC. Kinetic of vascular and cellular alterations in the carrageenin-induced peritonitis in Gallus gallus. Effect of steroidal and non-steroidal antiinflamatory drugs. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1994 Dec. 3 [cited 2024 May 28];31(3-4):173-80. Available from: https://www.revistas.usp.br/bjvras/article/view/52061