Resulting alterations at the level of testes and semen in dogs submitted to vincristine sulphate administra tion

Authors

  • Carlos Roberto Daleck Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Paulo Henrique Franceschini Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • João Guilherme Padilha Filho Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Antonio Carlos Alessi Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Joaquim Mansano Garcia Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Maria Izabel Mello Martins Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • João Moreira da Costa Neto Universidade Federal de Patos, PB.

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.1994.52090

Keywords:

Dogs, Vincristine sulphate, Semen, Antineoplastic agents

Abstract

Sperm analysis and testicular histological studies were performed before and after vincristine sulphate treatment, in fourteen male dogs. In group I (n = 8), unilateral orchiectomy was carried out before and after mitostatic treatment, and testicular and epididymal biopsies were examined histologically. All histological examinations showed a slight to moderate degeneration of testicular tissue. In group II (n = 6) semen was collected and was submitted to laboratorial analysis. After vincristine treatment, middle piece and tail abnormalities were found. However, as physical and morphological abnormalities showed to be reversible, vincristine sulphate therapy may be used in such species.

Downloads

Download data is not yet available.

Published

1995-03-01

How to Cite

Daleck, C. R., Franceschini, P. H., Padilha Filho, J. G., Alessi, A. C., Garcia, J. M., Martins, M. I. M., & Costa Neto, J. M. da. (1995). Resulting alterations at the level of testes and semen in dogs submitted to vincristine sulphate administra tion. Brazilian Journal of Veterinary Research and Animal Science, 32(1), 51-56. https://doi.org/10.11606/issn.1678-4456.bjvras.1994.52090

Issue

Section

ANIMAL PATHOLOGY