Effects of amitraz on the arterial blood pressure and body rectal temperature of conscious rats

Authors

  • Jorge Camilo Flório Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP.
  • Michiko Sakate Universidade Estadual Paulista, Faculdade de Medicina Veterinária, Botucatu, São Paulo, SP
  • João Palermo Neto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP.

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.1994.52103

Keywords:

Amitraz, Pesticides, Monoamine oxidase inhibitors

Abstract

The present study examined the effects of acute amitraz (100.0 mg/kg) administration on arterial blood pressure and body rectal temperature of male Wistar rats. Amitraz decreased arterial blood pressure and also produced hypothermia. Tyramine (100.0 mg/kg) administration induced a significant (p < 0.05) increase in the pressure of the rats dosed with the pesticide, but did not change the arterial blood pressure of the rats in the control group. Half of the rats given amitraz plus tyramine, but not the control solution plus tyramine died 3 to 10 hr after the drug administration. The indicative signs of intoxication included sedation, motor incoordination and coma. Yohimbine (10.0 mg/kg) did not change amitraz-induced hypotermia (p<0.05). Although possible action of amitraz on brain alpha2 noradrenergic receptors could not be excluded, the results were interpreted on a possible monoaminoxidase inhibitor (MAOI) - like action for the pesticide.

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Published

1995-09-03

How to Cite

Flório, J. C., Sakate, M., & Palermo Neto, J. (1995). Effects of amitraz on the arterial blood pressure and body rectal temperature of conscious rats. Brazilian Journal of Veterinary Research and Animal Science, 32(3), 160-164. https://doi.org/10.11606/issn.1678-4456.bjvras.1994.52103

Issue

Section

BASIC SCIENCES