Differences in blood glucose increase between horses receiving xylazine and detomidine for surgical and non-surgical clinical procedures

Authors

  • Aline Magalhães Ambrósio Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Andreia Gomes Casaes Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Keila Kazue Ida Universidade de São Paulo, Faculdade de Medicina, Laboratório de Investigação Médica - Lim 08, Programa de Pós-Graduação em Anestesiologia, São Paulo, SP
  • Maria Teresa de Melo Rego Souto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Leandro da Silva Zechetto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Hospital Veterinário, São Paulo, SP
  • Priscila Viau Furtado Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Reprodução Animal, São Paulo, SP
  • Patrícia Miyashiro Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica, São Paulo, SP
  • Carolina Castanho Mambre Bonomo Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Clínica Médica, São Paulo, SP
  • Guilherme Chiacchio Fernandes Faculdade Anhanguera de Campinas, Curso de Medicina Veterinária, Campinas, SP
  • Pedro Henrique de Carvalho Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Luis Claudio Lopes Correa da Silva Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Cirurgia, São Paulo, SP
  • Denise Tabacchi Fantoni Universidade de São Paulo, Faculdade de Medicina, Laboratório de Investigação Médica - Lim 08, Programa de Pós-Graduação em Anestesiologia, São Paulo, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.v49i6p493-499

Keywords:

Alpha-2 agonists, Cortisol, Gastroscopy, Arthroscopy, Horses

Abstract

The aim of this prospective randomized clinical study was to compare blood glucose and cortisol levels between horses receiving xylazine and detomidine for surgical and non-surgical procedures. Horses from non-surgical groups received 0.5 mg/kg of xylazine (GX group, n=5) or 0.01 mg/kg of detomidine (GD group, n=5) for gastroscopic examination. Horses from the surgical groups received similar doses of xylazine (AX group, n=7) or detomidine (AD group, n=7), followed by anesthetic induction with 2 mg/kg of ketamine and 0.05 mg/kg of diazepam for an arthroscopic procedure under isoflurane anesthesia. Blood samples were obtained prior to the alpha-2 agonist administration (baseline) and after 10, 30, 60 and 90 minutes. All groups had a significant increase in blood glucose from 30 to 90 minutes after alpha-2 agonist administration, compared to baseline. After receiving the alpha-2 agonist, the AD group had blood glucose levels (118-150 mg/dL) significantly higher than GD (99-119 mg/dL) and AX (97-116 mg/dL) groups. Cortisol had no significant changes within a group. However, the AX group had cortisol levels (3.6-3.7 mg/dL) significantly lower than GX group (5.4-5.7 mg/dL) from 30 to 90 minutes after xylazine administration. We concluded that blood glucose levels were when detomidine was administered for surgical procedure, compared to xylazine also for surgical procedure, and non-surgical procedure. Serum cortisol was minimally affected by administration of xylazine and detomidine regardless procedures were surgical or non-surgical.

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Published

2012-12-11

How to Cite

Ambrósio, A. M., Casaes, A. G., Ida, K. K., Souto, M. T. de M. R., Zechetto, L. da S., Furtado, P. V., Miyashiro, P., Bonomo, C. C. M., Fernandes, G. C., Carvalho, P. H. de, Silva, L. C. L. C. da, & Fantoni, D. T. (2012). Differences in blood glucose increase between horses receiving xylazine and detomidine for surgical and non-surgical clinical procedures. Brazilian Journal of Veterinary Research and Animal Science, 49(6), 493-499. https://doi.org/10.11606/issn.1678-4456.v49i6p493-499

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