Chloramphenicol restores the polymorphonuclear accumulation in carrageenin-induced pleurisy in diabetic rats
Keywords:Chloramphenicol, Diabetes, Pleurisia, Neutrophils
AbstractWe investigated the effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the reduced polymorphonuclear leukocytes (PMN) accumulation in carrageenin-induced pleurisy (150 mug) in diabetic (alloxan, 40 mg/kg, IV) rats (Wistar, males, 180-320 g, n = 12). Chloramphenicol produced an increase (p<0.05) on PMN count in pleural exudate of 36% in normal animals. In the animals non-treated with chloramphenicol the diabetes state reduced (p<0.05) the accumulation of PMN cells by 45%. In diabetic animals treated with chloramphenicol the number of PMN in pleural exudate was similar to the one observed in the control group. Total and differential counts of leukocytes in the peripheral blood were similar between groups before and 4 h after the carrageenin-injection.
Download data is not yet available.
How to Cite
Moraes, J. R. E. de, Moraes, F. R. de, & Engrácia Filho, J. R. (1998). Chloramphenicol restores the polymorphonuclear accumulation in carrageenin-induced pleurisy in diabetic rats. Brazilian Journal of Veterinary Research and Animal Science, 35(6), 243-245. https://doi.org/10.1590/S1413-95961998000600002
The journal content is authorized under the Creative Commons BY-NC-SA license (summary of the license: https://