Use of the Dorfman-Warnke classification (modified by Burke) in veterinary pathology in the evaluation of the lymphadenitis induced through canine parvovirus in guinea -pigs (Cavia porcellus )

Authors

  • José Guilherme Xavier Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
  • Adhemar Longatto Filho Instituto Adolfo Lutz, São Paulo, SP
  • Cristina Takami Kanamura Instituto Adolfo Lutz, São Paulo, SP
  • José Luiz Guerra Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP

DOI:

https://doi.org/10.1590/S1413-95961998000600004

Keywords:

Canine parvovirus, Lymphadenitis, Animal pathology

Abstract

In human pathology the adequate system used to analyze and interprete reactive lymphadenopathies is based on the morphological characterization of the various areas within the lymphoid node. In veterinary pathology there is no standardization of histopathological evaluation of lymph nodes. Therefore, in this study, we applied the Dorfman-Warnke (modified by Burke) human classification of reactive lymphadenopathies to evaluate virus-induced lymphadenitis in guinea-pigs. Canine parvovirus was inoculated into the footpads of guinea-pigs and the response of popliteal lymph nodes was histologically studied. The footpads were excised after different periods of time, processed, and stained with HE, Mallory, Gordon & Sweets, Giemsa and by immunohistochemical methods. A significant increase in the weight of ipsilateral lymph nodes to the inoculation site (p<0.05) was observed. The follicular response in the lymph nodes was characterized by the reaction of the germinative center, which showed partial loss of delimitation in the mantle zone. Increased numbers of blast cells and hypertrophy of post-capillary venules were evidenced in the paracortical area of the lymph nodes. There was a discrete hyperplasia of the medullary cords and a general enlargement of the reticular net associated with those alterations. The reactional response observed was similar to viral lymphadenitis identified in humans, justifying the attempts to systematize this classification for veterinary use just like it is currently done in human medicine.

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Published

1998-01-01

How to Cite

Xavier, J. G., Longatto Filho, A., Kanamura, C. T., & Guerra, J. L. (1998). Use of the Dorfman-Warnke classification (modified by Burke) in veterinary pathology in the evaluation of the lymphadenitis induced through canine parvovirus in guinea -pigs (Cavia porcellus ). Brazilian Journal of Veterinary Research and Animal Science, 35(6), 252-256. https://doi.org/10.1590/S1413-95961998000600004

Issue

Section

VETERINARY MEDICINE

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