Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats
DOI:
https://doi.org/10.1590/S1413-95961999000200008Keywords:
Milk, Pyrrolizidine alkaloids, Crotalaria spectabilis, PoisoningAbstract
Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat’s milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.Downloads
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Published
1999-01-01
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Section
VETERINARY MEDICINE
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How to Cite
1.
Medeiros RMT de, Górniak SL, Guerra JL. Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1999 Jan. 1 [cited 2024 Apr. 26];36(2):97-100. Available from: https://www.revistas.usp.br/bjvras/article/view/5769