Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats
Keywords:Milk, Pyrrolizidine alkaloids, Crotalaria spectabilis, Poisoning
AbstractSeeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat’s milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.
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How to Cite
Medeiros, R. M. T. de, Górniak, S. L., & Guerra, J. L. (1999). Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats. Brazilian Journal of Veterinary Research and Animal Science, 36(2), 97-100. https://doi.org/10.1590/S1413-95961999000200008
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