Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats

Authors

  • Rosane Maria Trindade de Medeiros Universidade Federal da Paraíba, Centro de Saúde e Tecnologia Rural, Departamento de Clínicas Veterinárias, Patos, PB
  • Silvana Lima Górniak Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Centro de Pesquisa em Toxicologia Veterinária, São Paulo, SP
  • José Luis Guerra Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP

DOI:

https://doi.org/10.1590/S1413-95961999000200008

Keywords:

Milk, Pyrrolizidine alkaloids, Crotalaria spectabilis, Poisoning

Abstract

Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat’s milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.

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Published

1999-01-01

Issue

Section

VETERINARY MEDICINE

How to Cite

1.
Medeiros RMT de, Górniak SL, Guerra JL. Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1999 Jan. 1 [cited 2024 Jul. 23];36(2):97-100. Available from: https://www.revistas.usp.br/bjvras/article/view/5769