Hematological and biochemical profiles of rats (Rattus norvegicus) kept under microenvironmental ventilation system

  • Maria Araújo Teixeira Universidade Federal de Mato Grosso do Sul, Biotério do Centro de Ciências Biológicas e da Saúde, Campo Grande, MS
  • Luziane do Carmo Andrade Guinski Chaguri Instituto Butantã, Biotério Central, São Paulo, SP
  • André Silva Carissimi Universidade Federal do Rio Grande do Sul, Faculdade de Medicina Veterinária, Departamento de Medicina Animal, Porto Alegre, RS
  • Nívea Lopes de Souza Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, SP
  • Claudia Madalena Cabrera Mori Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, SP
  • Valéria Maria Wanderley Gomes Mater Clínica, Laboratório de Análises Clínicas, Campo GRande, MS
  • Adelino Poli Neto Instituto Adolfo Lutz, São Paulo, SP
  • Kimiyo Nonoyama Instituto Adolfo Lutz, São Paulo, SP
  • José Luiz Bernardino Merusse Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo, SP
Keywords: Laboratory animals, Rats, Hematology, Biochemistry, Ventilation

Abstract

Previous studies reported that rats (Rattus norvegicus) kept under microenvironmental ventilation systems (MEV) present better productive and health parameters when compared to animals kept under general diluting ventilation (GDV). The objective of the present research trial was to evaluate hematological and biochemical profiles of rats kept under MVS. In order to achieve this objective, two different trials were designed: Trail 1 (E1), in which it was evaluated the reproductive performance of males and females submitted to two different air speed limits - FV1, from 0.03 to 0.26 m / sec and FV2, from 0.27 to 0.80 m / sec. In Trial 2 (E2) it was evaluated different bed change intervals (3, 5, 7 and 9 days), for males kept under constant air speed (0.5 m / sec). Values for hemogram and biochemical patterns of these animals were compared to those of rats kept under GDV. Results show statistical differences in some of the studied parameters not only for the comparison between GVD and E1 and GVD and E2, but also between both groups submitted to MEV (E1 and E2). However, values found for all studied parameters are inside the normal range reported for this species, what indicates that MEV does not induce important changes in the physiological parameters evaluated.

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Published
2000-01-01
How to Cite
Teixeira, M., Chaguri, L. do, Carissimi, A., Souza, N., Mori, C. M., Gomes, V. M., Poli Neto, A., Nonoyama, K., & Merusse, J. L. (2000). Hematological and biochemical profiles of rats (Rattus norvegicus) kept under microenvironmental ventilation system. Brazilian Journal of Veterinary Research and Animal Science, 37(5), 342-347. https://doi.org/10.1590/S1413-95962000000500001
Section
BASIC SCIENCES