Baypamun® action in hamsters experimentally infected with Leptospira interrogans serogroup Canicola

Authors

  • Hélio Langoni Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Núcleo de Pesquisas em Zoonoses, Departamento de Higiene Veterinária e Saúde Pública, Botucatu, SP
  • Rui Seabra Júnior Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Núcleo de Pesquisas em Zoonoses, Departamento de Higiene Veterinária e Saúde Pública, Botucatu, SP
  • Kenio Gouveia Cabral Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP
  • Eva Laurice Pereira Cunha Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Botucatu, SP

DOI:

https://doi.org/10.1590/S1413-95962001000600010

Keywords:

Immunomodulators, Leptospira, Immunity

Abstract

Baypamun® is an immunity modulator recommended as prophylactic and therapeutic use. In the present study, this product was used in the hamsters experimentally infected with Leptospira interrogans serogroup canicola. The animals were divided in 5 groups, with 20 animals each. This product was used as a therapeutic, prophylactic and as adjuvant. As a therapeutic use all the animals died. Despite of eight (40.0%) survivors, the prophylactic use wasn't also totally favorable due to leptospire recovering from kidneys of those animals. Based on the analysis of antibodies levels among animals that received vaccine and vaccine with Baypamun® as adjuvante, this product didn't conferred superior humoral answer. However, other studies should be accomplished utilizing this product in a longer period as well as verify the cellular answer by Baypamun® use as adjuvant in the infectious disease.

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Published

2001-01-01

How to Cite

Langoni, H., Seabra Júnior, R., Cabral, K. G., & Cunha, E. L. P. (2001). Baypamun® action in hamsters experimentally infected with Leptospira interrogans serogroup Canicola. Brazilian Journal of Veterinary Research and Animal Science, 38(6), 293-295. https://doi.org/10.1590/S1413-95962001000600010

Issue

Section

VETERINARY MEDICINE