The protective effects of Baypamun®HK in mice experimentally infected with Toxoplasma gondii

Authors

  • Eva Laurice Pereira Cunha Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Higiene Veterinária e Saúde Pública, Núcleo de Pesquisas em Zoonoses, Botucatu, SP
  • Rodrigo Costa da Silva Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Higiene Veterinária e Saúde Pública, Núcleo de Pesquisas em Zoonoses, Botucatu, SP
  • Aristeu Vieira Da Silva Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Higiene Veterinária e Saúde Pública, Núcleo de Pesquisas em Zoonoses, Botucatu, SP
  • Hélio Langoni Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Higiene Veterinária e Saúde Pública, Núcleo de Pesquisas em Zoonoses, Botucatu, SP

DOI:

https://doi.org/10.1590/S1413-95962004000300004

Keywords:

Toxoplasma gondii, Baypamun®HK, Indirect immunofluorescence, Mice

Abstract

The present work aimed to verify the effects of Baypamun®HK on the survival of albinic mice, experimentally infected with Toxoplasma gondii RH strain, treated or not with sulfadiazine-pirimetamine, as well as on the formation and the number of brain cysts. Four groups of 20 mices were inoculated with 10(5) tachizoites, subcutaneously, and undergone to different treatments. Serum tests were carried out by indirect immunofluorescence and samples of brain, liver and lung were collected from animals who died for cytological and brain cysts examinations. After 60 days, all survivors were sacrificed. Isolated Baypamun®HK didn't present a protective action against the infection by T. gondii, but its association sulfadiazine-pirimetamine, a specific treatment caused a higher survival of animals and a more intense and longer antibody responses.

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Published

2004-06-01

Issue

Vol. 41 No. 3 (2004)

Section

UNDEFINIED

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Cunha ELP, Silva RC da, Da Silva AV, Langoni H. The protective effects of Baypamun®HK in mice experimentally infected with Toxoplasma gondii. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2004 Jun. 1 [cited 2024 Apr. 18];41(3):169-72. Available from: https://www.revistas.usp.br/bjvras/article/view/6273