Evaluation of the adjuvant activity of dimethyl dioctadecyl ammonium chloride associated with the ammonium hydroxide to induction of humoral immune response of cattle vaccinated with bovine viral diarrhea virus

Authors

  • Luis César da Silva Universidade Estadual de Londrina, Londrina, PR
  • Elisabete Takiuchi Universidade Estadual de Londrina, Londrina, PR
  • Kerlei Cristina Médici Universidade Estadual de Londrina, Centro de Ciências Agrárias, Departamento de Medicina Veterinária Preventiva, Laboratório de Virologia Animal, Londrina, PR
  • Alice Fernandes Alfieri Universidade Estadual de Londrina, Centro de Ciências Agrárias, Departamento de Medicina Veterinária Preventiva, Laboratório de Virologia Animal, Londrina, PR
  • Amauri Alcindo Alfieri Universidade Estadual de Londrina, Centro de Ciências Agrárias, Departamento de Medicina Veterinária Preventiva, Laboratório de Virologia Animal, Londrina, PR

DOI:

https://doi.org/10.1590/S1413-95962004000300009

Keywords:

Cattle, Bovine viral diarrhea virus, Dimethyl dioctadecyl ammonium chloride, Vaccine, Adjuvant

Abstract

The humoral immune response of cattle vaccinated with inactivated bovine viral diarrhea virus (BVDV) using the association of dimethyl dioctadecyl ammonium chloride (DDA-chloride) and aluminum hydroxide (vaccine B) as adjuvant, was compared with the same antigenic formulation adsorbed with only aluminum hydroxide (vaccine A). The neutralizing antibodies titers were assessed two weeks after the second vaccine dose. The animals that received vaccine B had better humoral responses than the calves vaccinated with vaccine A. The mean titers of neutralizing antibodies, expressed in Log2, for the calves that received vaccine B was higher to those observed in group vaccinated with vaccine A. These results show that the inclusion of DDA chloride in vaccine formulations adsorbed with aluminum hydroxide determine a better humoral immune response in cattle vaccinated with BVDV inactivated.

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Published

2004-06-01

Issue

Vol. 41 No. 3 (2004)

Section

UNDEFINIED

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Silva LC da, Takiuchi E, Médici KC, Alfieri AF, Alfieri AA. Evaluation of the adjuvant activity of dimethyl dioctadecyl ammonium chloride associated with the ammonium hydroxide to induction of humoral immune response of cattle vaccinated with bovine viral diarrhea virus. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2004 Jun. 1 [cited 2024 Dec. 6];41(3):201-6. Available from: https://www.revistas.usp.br/bjvras/article/view/6278