Effect of porcine somatotropin on metabolism and testicular characteristics of prepubertal pigs

Authors

  • Viviane Rohrig Rabassa Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS
  • Elizabeth Schwegler Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS
  • Eduardo Schmitt Embrapa, Rondônia, RO
  • Augusto Schneider Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS
  • Camila Pizoni Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS
  • Cláudia Demarco Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS
  • Vinícius Farias Campos Universidade Federal de Pelotas, Centro de Desenvolvimento Tecnológico, Pelotas, RS
  • Tiago Collares Universidade Federal de Pelotas, Centro de Desenvolvimento Tecnológico, Pelotas, RS
  • Carmen Lucia Garcez Ribeiro Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS
  • Ana Lucia Pereira Schild Universidade Federal de Pelotas, Departamento de Patologia Animal, Pelotas, RS
  • Francisco Augusto Burkert Del Pino Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS
  • Ivan Bianchi Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS
  • Marcio Nunes Corrêa Universidade Federal de Pelotas, Departamento de Clínica Veterinária, Pelotas, RS

DOI:

https://doi.org/10.11606/issn.1678-4456.v51i1p60-67

Keywords:

Swine, Growth hormone, IGF-I, Testicle

Abstract

The effect of pST on the testicular characteristics and metabolic parameters of prepubertal pigs was evaluated. Experiment 1 aimed to determine the interval between applications of pST based on the concentrations of circulating IGF-I. Experiment 2 aimed to evaluate the effect of pST on metabolic parameters, testicular characteristics, and expression of GHR, IGF-I and PCNA. In Experiment 1 twelve piglets with 30 days of age were used. The pST Group (n=6) was submitted to one i.m. injection of pST and the Control Group (n=6) to one placebo injection. Blood collections were performed until d 7 post pST application to determine IGF-I concentration and metabolic profile. In Experiment 2 twelve piglets with 22 days of age were used. The pST Group was submitted to pST injections every three days, and the Control Group received placebo doses during 30 days. Blood collections were performed every 3 days. Samples of liver and testicular tissue were collected to determine gene expression and testicular characteristics. In Experiment 1 IGF-I concentration was higher for the pST Group (P=0.02). In Experiment 2 the pST Group had higher body and testicular weight (P=0.06) and increased gene expression of PCNA in testes (P<0.05). However, a reduction in the number of seminiferous tubules, and Sertoli cells, and in GHR expression (P<0.05) was observed. Thus, pST administration increased body and testis development in prepubertal pigs, however it reduced the density of seminiferous tubules and Sertoli cells.

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Published

2014-08-09

Issue

Section

ARTICLES

How to Cite

1.
Rabassa VR, Schwegler E, Schmitt E, Schneider A, Pizoni C, Demarco C, et al. Effect of porcine somatotropin on metabolism and testicular characteristics of prepubertal pigs. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2014 Aug. 9 [cited 2024 Jul. 16];51(1):60-7. Available from: https://www.revistas.usp.br/bjvras/article/view/62969