Effects of exposure to glyphosate in male and female mice behavior in pubertal period

Authors

  • Andréia de Oliveira Joaquim Universidade Paulista, Programa de Pós-Graduação em Patologia Ambiental e Experimental
  • Daclé Juliane Macrini Universidade Paulista, Programa de Pós-Graduação em Patologia Ambiental e Experimental
  • Esther Lopes Ricci Universidade Presbiteriana Mackenzie, Centro de Ciências Biológicas e da Saúde
  • Paula Andreotti Rodrigues Universidade Paulista, Programa de Pós-Graduação em Patologia Ambiental e Experimental
  • Helenice de Souza Spinosa Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia
  • Ivana Barbosa Suffredini Universidade Paulista, Programa de Pós-Graduação em Patologia Ambiental e Experimental
  • Maria Martha Bernarndi Universidade Paulista, Programa de Pós-Graduação em Patologia Ambiental e Experimental

DOI:

https://doi.org/10.11606/issn.1678-4456.v51i3p194-203

Keywords:

herbicide, animal behavior, sex differences, exploration, anxiety, depression

Abstract

The present study aims to investigate the effects of pre-pubertal exposure of male and female mice to a commercial formulation of glyphosate on sexual dimorphism observed in animal models of emotionality, anxiety and depression. For this, mice were exposed from 23 days of age (PND) until PND 45 to glyphosate (50 mg/kg, per os) or saline solution, and, ten days after the end of treatments, male and female mice were observed in the open field (OF), elevated plus maze (EPM) or forced swimming test (FWT). Results showed that exposure to glyphosate: 1) reduced the locomotion frequency of male mice similarly to female mice in the OF and female mice had an increase in rearing behavior and in the immobility time; 2) reduced in male mice the motor activity both in the OF and EPM, while no effects were observed in female mice; 3) in the SWT male mice had a decreased time of float similarly female mice. We concluded that pre-pubertal exposure to glyphosate reduced in male mice the capacity of exploration in the OF and EPM tests suggesting that the herbicide interfered with the central mechanism related to brain masculinization of exploratory and anxiety behavioral models. In the FWT it was observed a decreased depressive response in male mice while in female an increased response was detected.

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Published

2014-12-16

Issue

Section

ARTICLES

How to Cite

1.
Joaquim A de O, Macrini DJ, Ricci EL, Rodrigues PA, Spinosa H de S, Suffredini IB, et al. Effects of exposure to glyphosate in male and female mice behavior in pubertal period. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2014 Dec. 16 [cited 2024 Apr. 20];51(3):194-203. Available from: https://www.revistas.usp.br/bjvras/article/view/68454