c-Kit immunoexpression patterns differ in melanotic and amelanotic canine oral melanomas

Authors

  • Tarso Felipe Teixeira Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Laboratório de Oncologia Experimental e Comparada
  • Luciana Boffoni Gentile Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Laboratório de Oncologia Experimental e Comparada
  • Marco Antonio Leon Roman Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Laboratório de Oncologia Experimental e Comparada
  • Marco Antonio Gioso Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Laboratório de Oncologia Experimental e Comparada
  • Maria Lucia Zaidan Dagli Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Laboratório de Oncologia Experimental e Comparada

DOI:

https://doi.org/10.11606/issn.1678-4456.v52i4p333-341

Keywords:

Melanotic melanoma, Amelanotic melanoma, c-Kit, Immunohistochemistry, Dogs

Abstract

Melanomas are the most common oral malignancy in dogs. Cell proliferation and connexin expression has been shown to differ in canine melanotic and amelanotic oral melanomas. This study aimed to analyze the c-Kit protein expression in melanotic and amelanotic melanomas from canine buccal cavity. A total of 34 canine buccal melanomas (19 melanotic and 15 amelanotic).were collected. The amelanotic melanomas presented faster evolution and higher incidence of metastasis than melanotic tumors. A significantly higher number of c-Kit positive cells were observed in amelanotic neoplasms. In addition, the intensity of c-Kit immunolabeling was predominantly stronger in amelanotic melanomas. These results confirm a potential role for c-Kit in canine oral melanomas with clear differences in expression patterns between the two histological types of tumor, melanotic and amelanotic. This study highlights the importance of a detailed study of c-Kit mutations in canine oral melanomas to better understand the molecular mechanisms implicated in the development of this disease.

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Published

2015-12-10

Issue

Section

ARTICLES

How to Cite

1.
Teixeira TF, Gentile LB, Roman MAL, Gioso MA, Dagli MLZ. c-Kit immunoexpression patterns differ in melanotic and amelanotic canine oral melanomas. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2015 Dec. 10 [cited 2024 Jul. 19];52(4):333-41. Available from: https://www.revistas.usp.br/bjvras/article/view/82788