Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats

Authors

  • Andrea Lucia Natali Oliani Universidade Paulista e Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia
  • Lilian Mara Kirsch Dias Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia
  • Jeanete Lopes Naves Universidade de São Paulo, Instituto de Biociências
  • Maria Martha Bernardi Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia
  • Claudio Alvarenga Oliveira Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia

DOI:

https://doi.org/10.11606/issn.1678-4456.v52i2p141-150

Keywords:

Endocrine disruptors, Antiestrogen, Homosexual behavior, Ejaculation

Abstract

The effects of prenatal exposure to clomiphene citrate in sexual behavior, organ weight and hormone concentrations of male and female rats was evaluated. The animals received four doses of clomiphene citrate 2 mg/mL each during the prenatal period (21 days of gestation – DG21) on days 1 (DN1), 2 (DN2) and 3 (DN3) after the birth of the puppies. The treatment led to the development of polycystic ovaries in 70% of the females, masculinization of female sexual behavior and changes in sexual behavior of males evidenced by the reduction in the number of ejaculations. In regards to hormone levels, a decrease in the FSH levels in male offspring was observed. It was concluded that clomiphene citrate interferes with the reproductive capacity of male and female rats and female sexual orientation when prenatally administered.

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Author Biography

  • Andrea Lucia Natali Oliani, Universidade Paulista e Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia
    Doutora em Ciências na área de Reprodução Animal na FMVZ - USP (2012). Neurociências e Comportamento Animal. Mestre em ciências na área Fisiologia Geral, IBC - USP (2008) e Especialização em Clínica Médica Veterinária (2003). Professora Universitária pela Universidade Paulista ministrando aulas de Fisiologia Geral, Neurofisiologia, Fisiologia endócrina, Farmacologia, Técnicas Laboratoriais e bioensaios, Genética Humana e Genética Animal, Anatomia e Microbiologia.

Published

2015-06-30

Issue

Section

ARTICLES

How to Cite

1.
Oliani ALN, Dias LMK, Naves JL, Bernardi MM, Oliveira CA. Effects of perinatal period administration of clomiphene citrate in sexual behavior, organ weights and hormone concentration of Wistar male and female rats. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2015 Jun. 30 [cited 2024 Jun. 14];52(2):141-50. Available from: https://www.revistas.usp.br/bjvras/article/view/83354