Ventilation of rats with room air is more adequate than ventilation with pure oxygen

Authors

  • Marcus Vinicius Henriques de Carvalho Faculdade de Medicina de Jundiaí, Departamento de Cirurgia http://orcid.org/0000-0003-3911-370X
  • André José Fruchi Faculdade de Medicina de Jundiaí, Departamento de Cirurgia
  • Evaldo Marchi Faculdade de Medicina de Jundiaí, Departamento de Cirurgia

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2016.90632

Keywords:

Ventilation, Oxygen, Air, Rats

Abstract

The present study objective was to determine whether ventilation of rats with room air is possible and whether this technique has advantages when compared to pure oxygen ventilation. Twenty rats were divided into two groups of ten animals each. In one group, the animals were ventilated with cylinder of compressed air, 0.21 of oxygen, (air group), while the other group animals were ventilated with cylinder of compressed oxygen, assumed 1.00 of oxygen, (O2 group). Blood gas parameters and oxygenation index were compared between groups. The O2 group had hyperoxia at the beginning and end of artificial ventilation. The PaO2 were adequate in animals of air group. No significant difference in PaCO2 was observed between the two groups at the beginning or end of mechanical ventilation. The mean oxygenation index (PaO2/FiO2ratio) was significantly higher in the air group compared to the O2 group at the beginning and end of artificial ventilation (5 min: p < 0.001 and 60 min: p < 0. In conclusion, ventilation of rats with room air is more advantageous than with pure oxygen since it permits adequate oxygenation without causing hyperoxia.

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Published

2017-02-03

How to Cite

Carvalho, M. V. H. de, Fruchi, A. J., & Marchi, E. (2017). Ventilation of rats with room air is more adequate than ventilation with pure oxygen. Brazilian Journal of Veterinary Research and Animal Science, 53(4), 1-5. https://doi.org/10.11606/issn.1678-4456.bjvras.2016.90632

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