Acid base disorders in hospitalized cattle

Authors

  • Adriana Garzon-Audor Universidad Nacional de Colombia. Facultad de Medicina Veterinaria y Zootecnia.. Departamento de Salud Animal.
  • Olimpo Oliver-Espinosa Universidad Nacional de Colombia https://orcid.org/0000-0003-4669-1508
  • Rubiela Castañeda-Salazar Pontificia Universidad Javeriana. Facultad de Ciencias. Departamento de Microbiología.

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2020.159837

Keywords:

Bovine, Physicochemical approach, Strong ion acidosis, Hyponatremia

Abstract

The objectives of this retrospective study were to determine the main acid-base and electrolytes disorders in hospitalized cattle, using both Henderson-Hasselbalch and the physicochemical approach and to compare their diagnostic and therapeutic utility. A total of 31 medical records were reviewed of bovines admitted to the Large Animal Hospital at Universidad Nacional de Colombia, that met the inclusion criteria of the measurement of blood gases, blood electrolytes and plasma protein on admission before providing any treatment. Using the Henderson-Hasselbalch approach, acid base abnormalities were found in 83.3% of the patients, compared to 93.5% using the physicochemical approach. The principal acid-base disorders found were strong ion acidosis (61.29%) and weak acid acidosis (38.7%); strong ion gap (SIG) acidosis was found in 73.68% of cases showing strong ion acidosis. These results highlight the importance of the diagnosis of acid-base disorders in sick cattle for proper recognition of pathophysiological phenomena and its understanding to guide treatment decisions.

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Author Biography

  • Olimpo Oliver-Espinosa, Universidad Nacional de Colombia

    Olimpo Oliver E.  MV. MSc. DVSc

    Associate professor
    Large Animal Hospital
    Departament of Animal Health 
    Facultad de Medicina Veterinaria y de Zootecnia
    Universidad Nacional de Colombia

References

Barrington GM, Gay JM, Evermann JF. Biosecurity for neonatal gastrointestinal diseases. Vet Clin North Am Food Anim Pract. 2002;18(1):7-34. http://dx.doi.org/10.1016/S0749-0720(02)000051. PMid:12064170.

Berchtold J. Treatment of calf diarrhea: intravenous fluid therapy. Vet Clin North Am Food Anim Pract. 2009;25(1):73-99, vi. http://dx.doi.org/10.1016/j.cvfa.2008.10.001. PMid:19174284.

Braun U, Steiner A, Kaegi B. Clinical, haematological and biochemical findings and the results of treatment in cattle with acute functional pyloric stenosis. Vet Rec. 1990;126(5):107-10. PMid:2309403.

Butler DG, Willoughby RA, Mcsherry BJ. Studies on diarrhea in neonatal calves. 3. Acid-base and serum electrolyte values in normal calves from birth to ten days of age. Can J Comp Med. 1971;35(1):36-9. PMid:4251412.

Castañeda R, Moreno C, Oliver O, Donado P. Acid-base balance in bovine anaplasmosis. In Proceedings of the XXII World Buiatrics Congress; 2002; Hannover, Germany. Hannover: World Association for Buiatrics; 2002. p. 23-4.

Constable PD, Stämpfli HR, Navetat H, Berchtold J, Schelcher F. Use of a quantitative strong ion approach to determine the mechanism for acid-base abnormalities in sick calves with or without diarrhea. J Vet Intern Med. 2005;19(4):581-9. PMid:16095178.

Constable PD, Streeter RN, Koenig GJ, Perkins NR, Gohar HM, Morin DE. Determinants and utility of the anion gap in predicting hyperlactatemia in cattle. J Vet Intern Med. 1997;11(2):71-9. http://dx.doi.org/10.1111/j.1939-1676.1997. tb00076.x. PMid:9127293.

Constable PD, Walker PG, Morin DE, Foreman JH. 1998: Clinical and laboratory assessment of hydration status of neonatal calves with diarrhea. J Am Vet Med Assoc. 1998;212(7):991-6. PMid:9540870.

Constable PD. Calculation of variables describing plasma nonvolatile weak acids for use in the strong ion approach to acid-base balance in cattle. Am J Vet Res. 2002;63(4):482-90. http://dx.doi.org/10.2460/ajvr.2002.63.482. PMid:11939307.

Constable PD. Clinical assessment of acid-base status: comparison of the Henderson-Hasselbalch and strong ion approaches. Vet Clin Pathol. 2000;29(4):115-28. http://dx.doi.org/10.1111/j.1939165X.2000.tb00241.x. PMid:12070822.

Drackley JK. Calf nutrition from birth to breeding. Vet Clin North Am Food Anim Pract. 2008;24(1):55-86. http://dx.doi. org/10.1016/j.cvfa.2008.01.001. PMid:18299032.

Ewaschuk JB, Naylor JM, Palmer R, Whiting SJ, Zello GA. D-lactate production and excretion in diarrheic calves. J Vet Intern Med. 2004;18(5):744-7. http://dx.doi.org/10.1111/j.1939-1676.2004. tb02615.x. PMid:15515594.

Ewaschuk JB, Naylor JM, Zello GA. D-lactate in human and ruminant metabolism. J Nutr. 2005;135(7):1619-25. http:// dx.doi.org/10.1093/jn/135.7.1619. PMid:15987839.

Gentile A, Lorenz I, Sconza S, Klee W. Experimentally induced systemic hyperchloremic acidosis in calves. J Vet Intern Med. 2008;22(1):190-5. http://dx.doi.org/10.1111/j.1939-1676.2008.0028.x. PMid:18289309.

Gomez DE, Arroyo LG, Stämpfli HR, Cruz LE, Oliver OJ. Physicochemical interpretation of acid-base abnormalities in 54 adult horses with acute severe colitis and diarrhea. J Vet Intern Med. 2013a;27(3):548-53. http://dx.doi.org/10.1111/ jvim.12071. PMid:23551698.

Gomez DE, Lofstedt J, Stämpfli HR, Wichtel M, Muirhead T, Mcclure JT. Contribution of unmeasured anions to acid-base disorders and its association with altered demeanor in 264 calves with neonatal diarrhea. J Vet Intern Med. 2013b;27(6):1604-12. http://dx.doi.org/10.1111/jvim.12193. PMid:24107246.

Gordis L. Epidemiology. 4th ed. United States: Elsevier; 2009. 446 p.

Henderson LJ. The regulation of neutrality in the animal body. Science. 1913;37(950):389-95. http://dx.doi.org/10.1126/ science.37.950.389. PMid:17795147.

Kasari TR, Naylor JM. Further studies on the clinical features and clinicopathological findings of a syndrome of metabolic acidosis with minimal dehydration in neonatal calves. Can J Vet Res. 1986;50(4):502-8. PMid:3024795.

Kasari TR, Naylor JM. Metabolic acidosis without clinical signs of dehydration in young calves. The Canadian Veterinary. 1984;25(10):394-9. PMid:17422463.

Kasari TR, Woodbury AH, Morcom-Kasari E. Adverse effect of orally administered magnesium hydroxide on serum magnesium concentration and systemic acid-base balance in adult cattle. J Am Vet Med Assoc. 1990;196(5):735-42. PMid:2307611.

Lorenz I. D-Lactic acidosis in calves. Vet J. 2009;179(2):197-203. http://dx.doi.org/10.1016/j.tvjl.2007.08.028. PMid:17933565.

Naylor JM. A retrospective study of the relationship between clinical signs and severity of acidosis in diarrheic calves. Can Vet J. 1989;30(7):577-80. PMid:17423372.

Naylor JM. Severity and nature of acidosis in diarrheic calves over and under one week of age. Can Vet J. 1987;28(4):168-73. PMid:17422754.

Oetzel GR, Fettman MJ, Hamar DW, Olson JD. Screening of anionic salts for palatability, effects on acid-base status, and urinary calcium excretion in dairy cows. J Dairy Sci. 1991;74(3):96571. http://dx.doi.org/10.3168/jds.S0022-0302(91)78245-3. PMid:2071720.

Ogilvie TH, Butler DG, Gartley CJ, Dohoo IR. Magnesium oxide induced metabolic alkalosis in cattle. Can J Comp Med. 1983;47(2):108-11. PMid:6883181.

Omole OO, Nappert G, Naylor JM, Zello GA. Both L- and D-lactate contribute to metabolic acidosis in diarrheic calves. J Nutr. 2001;131(8):2128-31. http://dx.doi.org/10.1093/ jn/131.8.2128. PMid:11481406.

Ontario Veterinary College. Veterinary Teaching Hospital. Veterinary Hospital undergraduate manual. Ontario: Ontario Veterinary College, Veterinary Teaching Hospital; 1992.

Reinhold P, Hartmann H, Constable PD. Characterisation of acid-base abnormalities in pigs experimentally infected with Chlamydia suis. Vet J. 2010;184(2):212-8. http://dx.doi. org/10.1016/j.tvjl.2009.02.005. PMid:19286403.

Roussel AJ, Cohen ND, Holland PS, Taliaoferro L, Green R, Benson P, Navarre CB, Hooper RN. Alterations in acid-base balance and serum electrolyte concentrations in cattle: 632 cases (1984-1994). J Am Vet Med Assoc. 1998;212(11):176975. PMid:9621887.

Sławuta P, Nicpoń J, Skrzypczak P. Contemporary approach to acid-base balance and its disorders in dogs and cats. Pol. Pol J Vet Sci. 2010;13(3):561-7. PMid:21033575.

Stämpfli H, Oliver O. How to use the routine serum biochemical profile to understand and interpret acid- base disorders in the ruminant? In Proceedings of the XXII World Buiatrics Congress; 2002; Hannover, Germany. Hannover: World Association for Buiatrics; 2002. p. 23-4.

Stämpfli HR, Constable PD. Experimental determination of net protein charge and A(tot) and K(a) of nonvolatile buffers in human plasma. J Appl Physiol. 2003;95(2):620-30. http:// dx.doi.org/10.1152/japplphysiol.00100.2003. PMid:12665532.

Stämpfli HR, Oliver O, Pringle JK. Clinical evaluation of an oral electrolyte solution formulated based on Strong Ion Difference (SID) and using propionate as the organic anion in the treatment of neonatal diarrheic calves with strong ion acidosis. Open J Vet Med. 2012;2(1):34-9. http://dx.doi.org/10.4236/ojvm.2012.21006.

Stämpfli HR. Stewart Acid-Base Analysis [Internet]. Ontario: University of Guelph; 2019 [cited 2019 July 9]. Available from: http://www.uoguelph.ca/~pjf/1.4.html

Stewart PA. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol. 1983;61(12):1444-61. http://dx.doi. org/10.1139/y83-207. PMid:6423247.

Swets JA. Measuring the accuracy of diagnostic systems. Science. 1988;240(4857):1285-93. http://dx.doi.org/10.1126/ science.3287615. PMid:3287615.

Tennant B, Harrold D, Reina-Guerra M. Physiologic and metabolic factors in the pathogenesis of neonatal enteric infections in calves. J Am Vet Med Assoc. 1972;161(9):993-1007. PMid:4563254.

Ward JL, Smith DF, Fubini SL, Deuel-Aromando DM. Evaluation of abomasal outflow diversion as an experimental model of hypochloremic, hypokalemic metabolic alkalosis in lactating cows. Can J Vet Res. 1994;58(1):13-9. PMid:8143247.

Whitehair KJ, Haskins SC, Whitehair JG, Pascoe PJ. Clinical applications of quantitative acid-base chemistry. J Vet Intern Med. 1995;9(1):1-11. http://dx.doi.org/10.1111/j.1939-1676.1995. tb03265.x. PMid:7891356.

Wilkes P. Hypoproteinemia, strong-ion difference, and acid-base status in critically ill patients. J Appl Physiol. 1998;84(5):1740-8. http://dx.doi.org/10.1152/jappl.1998.84.5.1740. PMid:9572825.

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Published

2020-03-30

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How to Cite

1.
Garzon-Audor A, Oliver-Espinosa O, Castañeda-Salazar R. Acid base disorders in hospitalized cattle. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2020 Mar. 30 [cited 2024 Apr. 19];57(1):e159837. Available from: https://www.revistas.usp.br/bjvras/article/view/159837