Comparison of the effects of romifidine and an emulsion of amitraz on sedation and spontaneous locomotor activity of horses

Authors

  • Marina Ceccato Mendes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Renata Gemio dos Reis Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Carlos Augusto Araújo Valadão Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Antonio de Queiroz-Neto Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2008.26689

Keywords:

Amitraz, Romifidine, Sedation, Spontaneous, Locomotor Activity, Horses

Abstract

Amitraz (AM) and romifidine (RMF), two alpha-2 adrenoceptor agonists, produce sedative effect and decrease spontaneous locomotor activity (SLA) of horses. The behavioral effects and sedation after intravenous injection of RMF (0.06mg/kg) or AM 0.1mg/kg (AM 0.1) or AM 0.4mg/kg (AM 0.4) were compared in horses. RMF caused head ptosis (HP) until 45 min. The lower AM dose induced HP from 45 to 60 minutes and from 120 to 150 minutes, and the higher dose induced HP until 180 minutes. Data concerning changes in SLA were not conclusive. RMF or AM 0.4 caused a greater sedation than AM 0.1 until 20 min. After 20 minutes, the sedation caused by AM 0.4 was greater than that of RMF or AM 0.1. Romifidine caused consistent sedation until 45 minutes. The amitraz emulsion produced a dose-dependent sedation until 180 minutes. Comparing to romifidine, the emulsion of amitraz induced a more substantial sedation. At dosages and dilution applied, amitraz is an effective sedative for horses.

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Published

2008-08-01

Issue

Vol. 45 No. 4 (2008)

Section

UNDEFINIED

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Mendes MC, Reis RG dos, Valadão CAA, Queiroz-Neto A de. Comparison of the effects of romifidine and an emulsion of amitraz on sedation and spontaneous locomotor activity of horses. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2008 Aug. 1 [cited 2024 Apr. 16];45(4):298-304. Available from: https://www.revistas.usp.br/bjvras/article/view/26689