Heart implantation in subcutaneous tissue of isogenic mice. Study of an experimental model

Abstract

An experimental model of heart implantation in mice was studied, in accordance to the feasibility, post-surgical kinetics by histopathology and practical application. Isogenic animals from BALB/c and C57BL/10 strains were used, supplied by the Animal House of the Department of Parasitology, Microbiology and Imnunology of FMRP-USP. The experimental protocols were performed according to the operatory steps of the implantation of hearts extracted from just-born donors to the subcutaneous space of the dorsal face of the ear of adult singeneic and non singeneic receptors. Obtained results showed, basically, good feasibility and success in singeneic implantation. For non singeneics, there was sistematic rejection. The analysis altogether of the studied parameters allows to foresee the great utility of the model and the subsides that will bring to further studies in the field of alotransplantation.