Resulting alterations at the level of testes and semen in dogs submitted to vincristine sulphate administra tion

Authors

  • Carlos Roberto Daleck Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Paulo Henrique Franceschini Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • João Guilherme Padilha Filho Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Antonio Carlos Alessi Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Joaquim Mansano Garcia Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • Maria Izabel Mello Martins Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP.
  • João Moreira da Costa Neto Universidade Federal de Patos, PB.

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.1994.52090

Keywords:

Dogs, Vincristine sulphate, Semen, Antineoplastic agents

Abstract

Sperm analysis and testicular histological studies were performed before and after vincristine sulphate treatment, in fourteen male dogs. In group I (n = 8), unilateral orchiectomy was carried out before and after mitostatic treatment, and testicular and epididymal biopsies were examined histologically. All histological examinations showed a slight to moderate degeneration of testicular tissue. In group II (n = 6) semen was collected and was submitted to laboratorial analysis. After vincristine treatment, middle piece and tail abnormalities were found. However, as physical and morphological abnormalities showed to be reversible, vincristine sulphate therapy may be used in such species.

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Published

1995-03-01

Issue

Vol. 32 No. 1 (1995)

Section

ANIMAL PATHOLOGY

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Daleck CR, Franceschini PH, Padilha Filho JG, Alessi AC, Garcia JM, Martins MIM, et al. Resulting alterations at the level of testes and semen in dogs submitted to vincristine sulphate administra tion. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1995 Mar. 1 [cited 2024 Apr. 25];32(1):51-6. Available from: https://www.revistas.usp.br/bjvras/article/view/52090