Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats

Authors

  • Rosane Maria Trindade de Medeiros Universidade Federal da Paraíba, Centro de Saúde e Tecnologia Rural, Departamento de Clínicas Veterinárias, Patos, PB
  • Silvana Lima Górniak Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, Centro de Pesquisa em Toxicologia Veterinária, São Paulo, SP
  • José Luis Guerra Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP

DOI:

https://doi.org/10.1590/S1413-95961999000200008

Keywords:

Milk, Pyrrolizidine alkaloids, Crotalaria spectabilis, Poisoning

Abstract

Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat’s milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk.

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Published

1999-01-01

Issue

Vol. 36 No. 2 (1999)

Section

VETERINARY MEDICINE

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Medeiros RMT de, Górniak SL, Guerra JL. Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1999 Jan. 1 [cited 2024 Apr. 16];36(2):97-100. Available from: https://www.revistas.usp.br/bjvras/article/view/5769