The role of prolactin in prostatic inflammation

Authors

  • Edson João da Silva Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
  • Maria Lucia Zaidan-Dagli Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
  • Antonia Gladys Nasello Universidade de São Paulo, Faculdade de Odontologia, Departamento de Fisiologia, Ribeirão Preto, SP
  • Janete Aparecida Anselmo-Franci Santa Casa, Faculdade de Ciências Médicas, Departamento de Ciências Fisiológicas, São Paulo, SP
  • Luciano Freitas Felicio Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.v50i6p468-473

Keywords:

Hyperprolactinemia, Domperidone, Prostate, Rats

Abstract

Several reports have shown that prolactin (PRL) plays a role in prostatic growth, but few studies considered the role of PRL in the process of prostatic inflammation. Young (45 ± 5 days old) and adult (75 ± 5 days old) male Wistar rats were subcutaneously injected daily with domperidone (4.0 mg.kg-1) to maintain high serum PRL levels. The animals were treated for 15, 30, 45 or 60 days. Blood and prostate samples were collected at the end of each treatment for PRL dosage and histological analysis, respectively. Only young animals treated with DOMP for 15 and 30 days displayed inflammatory infiltrate in the prostate. These results confirm literature data in regards to PRL involvement in inducing prostate inflammation. Moreover, it was concluded that young animals are more susceptible then adults to the PRL action concerning prostate inflammation.

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Published

2013-12-09

Issue

Section

ARTICLES

How to Cite

The role of prolactin in prostatic inflammation. (2013). Brazilian Journal of Veterinary Research and Animal Science, 50(6), 468-473. https://doi.org/10.11606/issn.1678-4456.v50i6p468-473